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萜类化合物抗乳腺癌信号通路机制的研究进展

Research progress on the signaling pathway mechanism of terpenoids against breast cancer.

作者信息

Tu Sheng-Nan, Hu Fen, Zhang Juan, Cai Haifeng, Yang Junquan

机构信息

School of Clinical Medicine, North China University of Science and Technology, Tangshan, 063210, China.

College of Life Sciences, North China University of Science and Technology, Tangshan, 063210, China.

出版信息

Discov Oncol. 2025 Mar 31;16(1):433. doi: 10.1007/s12672-025-01881-0.

Abstract

Breast cancer is the most common malignant tumor in women worldwide. Current treatments include chemotherapy, hormone therapy, radiotherapy and surgery. Terpenoids have great anti-cancer potential due to their anti-inflammatory, antioxidant, anti-tumor, antiviral and other biological activities. They have become the central drug for the prevention and treatment of breast cancer. However, their low bioavailability and stability are urgent issues that need to be addressed. This article aims to sort out the mechanism of action of terpenoids in the treatment of breast cancer. By reviewing different signal transduction pathways, it is hoped that new ideas for the joint action of multiple pathways and multiple targets will be provided, and a theoretical basis will be provided for improving basic research and clinical treatment of breast cancer.

摘要

乳腺癌是全球女性中最常见的恶性肿瘤。目前的治疗方法包括化疗、激素治疗、放疗和手术。萜类化合物因其抗炎、抗氧化、抗肿瘤、抗病毒等生物活性而具有巨大的抗癌潜力。它们已成为预防和治疗乳腺癌的核心药物。然而,它们的低生物利用度和稳定性是亟待解决的问题。本文旨在梳理萜类化合物治疗乳腺癌的作用机制。通过综述不同的信号转导途径,希望能为多途径、多靶点联合作用提供新思路,为改善乳腺癌的基础研究和临床治疗提供理论依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7555/11958888/c6e2b410e390/12672_2025_1881_Fig1_HTML.jpg

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