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金属基诊疗一体化纳米粒子用于癌症治疗和成像的研究进展

Review on Metal-Based Theranostic Nanoparticles for Cancer Therapy and Imaging.

机构信息

Toronto, ON, Canada.

出版信息

Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231191493. doi: 10.1177/15330338231191493.

DOI:10.1177/15330338231191493
PMID:37642945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10467409/
Abstract

Theranostic agents are promising due to their ability to diagnose, treat and monitor different types of cancer using a variety of imaging modalities. The advantage specifically of nanoparticles is that they can accumulate easily at the tumor site due to the large gaps in blood vessels near tumors. Such high concentration of theranostic agents at the target site can lead to enhancement in both imaging and therapy. This article provides an overview of nanoparticles that have been used for cancer theranostics, and the different imaging, treatment options and signaling pathways that are important when using nanoparticles for cancer theranostics. In particular, nanoparticles made of metal elements are emphasized due to their wide applications in cancer theranostics. One important aspect discussed is the ability to combine different types of metals in one nanoplatform for use as multimodal imaging and therapeutic agents for cancer.

摘要

治疗诊断试剂具有很大的应用潜力，因为它们能够利用各种成像方式对不同类型的癌症进行诊断、治疗和监测。纳米粒子的优势在于，由于肿瘤附近的血管存在较大的间隙，它们很容易在肿瘤部位聚集。治疗诊断试剂在靶部位的高浓度可以同时增强成像和治疗效果。本文概述了用于癌症治疗诊断的纳米粒子，以及在使用纳米粒子进行癌症治疗诊断时，成像、治疗选择和信号通路的重要性。特别强调了由金属元素制成的纳米粒子，因为它们在癌症治疗诊断中有广泛的应用。本文讨论的一个重要方面是将不同类型的金属结合在一个纳米平台中，作为癌症多模态成像和治疗试剂的能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/3cefd0c3b50c/10.1177_15330338231191493-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/e7d1b7ebaa1d/10.1177_15330338231191493-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/edb621749bc3/10.1177_15330338231191493-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/fc57cc59c5ed/10.1177_15330338231191493-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/8cfca47b4e4b/10.1177_15330338231191493-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/8c7940b3a813/10.1177_15330338231191493-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/3edcf0ab0ace/10.1177_15330338231191493-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/58df097ed0f4/10.1177_15330338231191493-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/ac323b200725/10.1177_15330338231191493-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/3cefd0c3b50c/10.1177_15330338231191493-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/e7d1b7ebaa1d/10.1177_15330338231191493-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/edb621749bc3/10.1177_15330338231191493-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/fc57cc59c5ed/10.1177_15330338231191493-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/8cfca47b4e4b/10.1177_15330338231191493-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/8c7940b3a813/10.1177_15330338231191493-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/3edcf0ab0ace/10.1177_15330338231191493-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/58df097ed0f4/10.1177_15330338231191493-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/ac323b200725/10.1177_15330338231191493-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bb1/10467409/3cefd0c3b50c/10.1177_15330338231191493-fig9.jpg

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Review on Metal-Based Theranostic Nanoparticles for Cancer Therapy and Imaging.

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本文引用的文献

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PDGFB targeting biodegradable FePt alloy assembly for MRI guided starvation-enhancing chemodynamic therapy of cancer.

J Nanobiotechnology. 2022-6-7

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Int J Mol Sci. 2022-4-30

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RSC Adv. 2018-2-9

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