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一名孕妇发生单纯疱疹病毒肝炎致死病例。

A fatal case of herpes simplex virus hepatitis in a pregnant patient.

作者信息

Masadeh Maen, Shen Huafeng, Lee Yejin, Gunderson Alan, Brown Kyle, Bellizzi Andrew, Tanaka Tomohiro

机构信息

Division of Gastroenterology and Hepatology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

出版信息

Intractable Rare Dis Res. 2017 May;6(2):124-127. doi: 10.5582/irdr.2017.01013.

DOI:10.5582/irdr.2017.01013
PMID:28580213
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5451744/
Abstract

We present a middle aged pregnant woman who developed signs and symptoms of acute liver failure and was found to have herpes simplex virus hepatitis. Patient had an emergent delivery and was started on antiviral therapy, but unfortunately due to the severity of her liver failure, she passed away. The importance of reporting this case is to emphasize on the importance of considering herpes simplex infection in pregnant women who present with acute liver failure, and the importance of early administration of antiviral therapy.

摘要

我们报告了一名中年孕妇,她出现了急性肝衰竭的症状和体征,被诊断为单纯疱疹病毒性肝炎。患者紧急分娩并开始接受抗病毒治疗,但不幸的是,由于肝衰竭严重,她最终去世。报告该病例的重要性在于强调对于出现急性肝衰竭的孕妇,考虑单纯疱疹感染的重要性,以及早期给予抗病毒治疗的重要性。

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本文引用的文献

1
Pregnancy and infection.妊娠与感染
N Engl J Med. 2014 Jun 5;370(23):2211-8. doi: 10.1056/NEJMra1213566.
2
Antiviral-resistant fulminant herpes hepatitis in pregnancy.妊娠期抗病毒耐药性暴发性疱疹性肝炎
AJP Rep. 2013 Oct;3(2):87-90. doi: 10.1055/s-0033-1343791. Epub 2013 May 21.
3
Acute liver failure caused by herpes simplex virus in a pregnant patient: is there a potential role for therapeutic plasma exchange?一名孕妇因单纯疱疹病毒引起的急性肝衰竭:治疗性血浆置换有潜在作用吗?
J Clin Apher. 2013 Dec;28(6):426-9. doi: 10.1002/jca.21287. Epub 2013 Jul 16.
4
Fulminant gestational hepatitis due to primary herpes simplex type 2 infection: use of serum HSV polymerase chain reaction for noninvasive diagnosis.原发性单纯疱疹病毒 2 型感染导致的暴发性妊娠性肝炎:应用血清 HSV 聚合酶链反应进行无创诊断。
Diagn Microbiol Infect Dis. 2012 Feb;72(2):181-4. doi: 10.1016/j.diagmicrobio.2011.10.005. Epub 2011 Nov 21.
5
Antiviral drugs for viruses other than human immunodeficiency virus.抗其他病毒药物(不包括人类免疫缺陷病毒)。
Mayo Clin Proc. 2011 Oct;86(10):1009-26. doi: 10.4065/mcp.2011.0309.
6
Herpes simplex virus hepatitis - it's high time we consider empiric treatment.单纯疱疹病毒肝炎——现在是我们考虑经验性治疗的时候了。
J Gastrointestin Liver Dis. 2011 Mar;20(1):93-6.
7
Fulminant herpes simplex virus hepatic failure in pregnancy requiring liver transplantation.妊娠期暴发性单纯疱疹病毒肝衰竭需行肝移植术
Aust N Z J Obstet Gynaecol. 2010 Oct;50(5):492-4. doi: 10.1111/j.1479-828X.2010.01193.x.
8
A case of fulminant hepatic failure in pregnancy.一例妊娠合并暴发性肝衰竭病例。
Hepatology. 2010 Jan;51(1):341-2. doi: 10.1002/hep.23372.
9
Herpes simplex virus hepatitis: an analysis of the published literature and institutional cases.单纯疱疹病毒性肝炎:已发表文献及机构病例分析
Liver Transpl. 2007 Oct;13(10):1428-34. doi: 10.1002/lt.21250.
10
Herpes simplex virus hepatitis causing acute liver dysfunction and thrombocytopenia in pregnancy.单纯疱疹病毒肝炎导致妊娠期急性肝功能障碍和血小板减少症。
Obstet Gynecol. 2005 Nov;106(5 Pt 2):1187-9. doi: 10.1097/01.AOG.0000160481.11517.a0.