Tirumani Prabhakar, Venu S, Sridhar G, Praveen Kumar M, Rajashekhar A V, Naga Raju T
a Department of Zoology , Osmania University , Hyderabad , India.
Nat Prod Res. 2018 Jun;32(11):1295-1298. doi: 10.1080/14786419.2017.1333991. Epub 2017 Jun 5.
Hemidesmus indicus (L.) R. Br. was extensively used as hypoglycaemic agent and significance of this plant on secondary complications of diabetes remained unknown. The present study was to investigate the anti-cataractous activity of H. indicus against streptozotocin (STZ)-induced diabetic cataract in rodent model. Root extracts have been prepared and tested for inhibition of rat lens aldose reductase (AR) activity. In addition, its pharmacological potential has been investigated in STZ-induced diabetic cataract. Methanol extract of H. indicus-inhibited AR activity in vitro decreased the blood glucose levels, inhibited the AR activity and delayed the onset and progression of cataract in a dose-dependent manner in in vivo and the antioxidant markers have been normalised. Our results demonstrate that H. indicus has decrease the osmotic stress by inhibiting the AR activity and prevented the loss of antioxidants and delayed the progression of diabetic cataract in STZ-induced diabetic rats.
印度牛弭草（Hemidesmus indicus (L.) R. Br.）被广泛用作降血糖药物，而这种植物对糖尿病并发症的意义仍不明确。本研究旨在探讨印度牛弭草对链脲佐菌素（STZ）诱导的啮齿动物模型糖尿病性白内障的抗白内障活性。制备了根提取物并测试其对大鼠晶状体醛糖还原酶（AR）活性的抑制作用。此外，还研究了其在STZ诱导的糖尿病性白内障中的药理潜力。印度牛弭草的甲醇提取物在体外抑制AR活性，在体内以剂量依赖的方式降低血糖水平、抑制AR活性并延缓白内障的发生和发展，且抗氧化标志物已恢复正常。我们的结果表明，印度牛弭草通过抑制AR活性降低了渗透压应激，防止了抗氧化剂的损失，并延缓了STZ诱导的糖尿病大鼠糖尿病性白内障的进展。
