Verk Barbara, Nemec Svete Alenka, Salobir Janez, Rezar Vida, Domanjko Petrič Aleksandra
Small Animal Clinic, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia (Verk, Nemec Svete, Domanjko Petrič).
Institute of Nutrition, Biotechnical Faculty, University of Ljubljana, Domžale, Slovenia (Salobir, Rezar).
J Vet Diagn Invest. 2017 Sep;29(5):636-644. doi: 10.1177/1040638717711995. Epub 2017 Jun 4.
We tested the hypothesis that indirect measures of oxidative stress (vitamin E, glutathione peroxidase, and malondialdehyde) differ in dogs in heart failure resulting from either myxomatous mitral valve disease or dilated cardiomyopathy. Dogs were classified according to the International Small Animal Cardiac Health Council (ISACHC) classification. Additionally, the effect of cardiac therapy on oxidative stress parameters and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in advanced stages of congestive heart failure was investigated. There were no significant differences in oxidative stress parameters between healthy dogs and the individual groups of cardiac patients. Significantly lower malondialdehyde (MDA) was observed in the ISACHC II group in comparison to ISACHC groups III and I. A significant positive correlation in treated patients was observed between NT-proBNP and MDA, NT-proBNP and vitamin E, as well as between MDA and vitamin E (and lipid-standardized vitamin E). No significant differences in any of the measured parameters were found between treated and non-treated cardiac patients. Our results suggest an association between MDA (the extent of lipid peroxidation) and NT-proBNP, vitamin E and NT-proBNP, as well as between MDA and vitamin E in treated canine patients. Plasma vitamin E concentration was maintained in all stages of cardiovascular disease in these canine patients.
对于因黏液瘤性二尖瓣疾病或扩张型心肌病导致心力衰竭的犬类，氧化应激的间接指标（维生素E、谷胱甘肽过氧化物酶和丙二醛）存在差异。犬类根据国际小动物心脏健康委员会（ISACHC）的分类进行划分。此外，还研究了心脏治疗对充血性心力衰竭晚期氧化应激参数和N末端B型利钠肽原（NT-proBNP）的影响。健康犬类与各心脏病患者组之间的氧化应激参数无显著差异。与ISACHC III组和I组相比，ISACHC II组的丙二醛（MDA）显著降低。在接受治疗的患者中，观察到NT-proBNP与MDA、NT-proBNP与维生素E以及MDA与维生素E（和脂质标准化维生素E）之间存在显著正相关。在接受治疗和未接受治疗的心脏病患者之间，任何测量参数均未发现显著差异。我们的结果表明，在接受治疗的犬类患者中，MDA（脂质过氧化程度）与NT-proBNP、维生素E与NT-proBNP以及MDA与维生素E之间存在关联。在这些犬类患者的心血管疾病各阶段，血浆维生素E浓度均保持稳定。
