Schroers M, Reiser K, Alexander T, Zablotski Y, Meyer-Lindenberg A
Veterinary Faculty, Ludwig-Maximilians-Universitat Munchen, Munchen, Germany.
Tierklinik Gessertshausen, Munich, Germany.
J Vet Dent. 2025 May;42(3):182-188. doi: 10.1177/08987564241248042. Epub 2024 May 1.
The study investigated whether malondialdehyde (MDA), a biomarker for oxidative stress, can be used as a viable parameter in dog saliva for the diagnosis or early detection of periodontal disease (PD). Saliva MDA concentrations were measured preoperatively in dogs diagnosed with PD during dental prophylaxis and compared with those of dentally healthy dogs. 35 dogs were included in the study. The average MDA concentration was 270 ng/ml (range 27-633) in the dogs without PD (n = 10) and 183 (36-833) ng/ml (ng/ml) in the dogs with PD (n = 25). The maximum MDA concentration in the study group (PD ≥1) was 833 ng/ml, which was significantly higher than in the study group (PD = 0) (p<0.05). The study showed that salivary MDA concentrations could not distinguish between healthy dogs and those with PD.
该研究调查了氧化应激生物标志物丙二醛（MDA）是否可作为犬唾液中的一个可行参数，用于牙周病（PD）的诊断或早期检测。在牙齿预防性治疗期间，对诊断为PD的犬术前测量唾液MDA浓度，并与牙齿健康的犬进行比较。该研究纳入了35只犬。无PD的犬（n = 10）的平均MDA浓度为270 ng/ml（范围27 - 633），患有PD的犬（n = 25）的平均MDA浓度为183（36 - 833）ng/ml。研究组（PD≥1）的最大MDA浓度为833 ng/ml，显著高于研究组（PD = 0）（p<0.05）。该研究表明，唾液MDA浓度无法区分健康犬和患有PD的犬。
