Druzhaeva Natalia, Nemec Svete Alenka, Tavčar-Kalcher Gabrijela, Babič Janja, Ihan Alojz, Pohar Katka, Krapež Uroš, Domanjko Petrič Aleksandra
Small Animal Clinic, Veterinary Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.
Institute of Food Safety, Feed and Environment, University of Ljubljana, 1000 Ljubljana, Slovenia.
Antioxidants (Basel). 2022 Jul 22;11(8):1427. doi: 10.3390/antiox11081427.
Scarce data exist on the effects of coenzyme Q (CoQ) supplementation in dogs with myxomatous mitral valve disease (MMVD). The purpose of this study was to investigate the effect of CoQ supplementation on oxidative stress markers (glutathione peroxidase, F2-isoprostanes), markers of inflammation (tumor necrosis factor-α, TNF soluble receptor II, leucocytes, and their subtypes), lymphocyte subpopulations (T helper and cytotoxic T lymphocytes, including activated T lymphocytes, and B lymphocytes), and echocardiographic and clinical parameters in dogs with MMVD. In this randomized, controlled, double-blind, longitudinal study, 43 MMVD dogs in stages ACVIM (American College of Veterinary Internal Medicine classification) B2 and ACVIM C and D (congestive heart failure (CHF)) received water-soluble coenzyme Q (100 mg twice daily) or placebo for 3 months, and 12 non-supplemented healthy dogs served as controls. All parameters were measured before and after supplementation in MMVD dogs and once in healthy dogs. CoQ supplementation had a positive impact on neutrophil percentage, lymphocyte percentage, and lymphocyte concentration in our cohort of dogs with CHF (ACVIM C and D). Conclusion: CoQ as an oral supplement may have benefits in terms of decreasing inflammation in dogs with MMVD and CHF.
关于辅酶Q（CoQ）补充剂对患有黏液瘤性二尖瓣疾病（MMVD）的犬类的影响，现有数据稀缺。本研究的目的是调查补充CoQ对MMVD犬类氧化应激标志物（谷胱甘肽过氧化物酶、F2-异前列腺素）、炎症标志物（肿瘤坏死因子-α、肿瘤坏死因子可溶性受体II、白细胞及其亚型）、淋巴细胞亚群（辅助性T淋巴细胞和细胞毒性T淋巴细胞，包括活化T淋巴细胞和B淋巴细胞）以及超声心动图和临床参数的影响。在这项随机、对照、双盲、纵向研究中，43只处于美国兽医内科学会（ACVIM）分类B2期以及ACVIM C期和D期（充血性心力衰竭（CHF））的MMVD犬类接受了水溶性辅酶Q（每日两次，每次100毫克）或安慰剂治疗3个月，12只未补充的健康犬类作为对照。在MMVD犬类补充前后以及在健康犬类中各测量一次所有参数。在我们患有CHF（ACVIM C期和D期）的犬类队列中，补充CoQ对中性粒细胞百分比、淋巴细胞百分比和淋巴细胞浓度有积极影响。结论：CoQ作为口服补充剂可能在减轻患有MMVD和CHF的犬类炎症方面有益。
