Halpern-Sebold L R, Margolis-Kazan H, Schreibman M P, Joh T H
Proc Soc Exp Biol Med. 1985 Mar;178(3):486-9. doi: 10.3181/00379727-178-rc1.
Immunoreactive tyrosine hydroxylase (ir-TH), the rate-limiting enzyme for the synthesis of dopamine and other catecholamines, was localized in the brain and pituitary gland of sexually mature platyfish (Xiphophorus maculatus). This is the first report of ir-TH in the nucleus olfactoretinalis, an LHRH-containing nucleus in the brain which plays an important role in the development and functioning of the reproductive system in platyfish. Ir-TH was also localized in the nucleus preopticus and paraventricular organ. In the pituitary gland ir-TH is found in the prolactin cells and in some fish, in some of the gonadotropin-containing cells of the pars intermedia, but not in the gonadotrops of the pars distalis. The localization of ir-TH in brain centers and pituitary cells associated with reproductive system regulation is discussed in the context of the interaction of monamines, neuropeptides and pituitary hormones during the maturation and operation of the brain-pituitary-gonadal axis.
免疫反应性酪氨酸羟化酶（ir-TH）是多巴胺和其他儿茶酚胺合成的限速酶，它定位于性成熟剑尾鱼（Xiphophorus maculatus）的脑和垂体中。这是ir-TH在嗅视网膜核中的首次报道，嗅视网膜核是脑中一个含促性腺激素释放激素的核，在剑尾鱼生殖系统的发育和功能中起重要作用。ir-TH也定位于视前核和室旁器官。在垂体中，ir-TH存在于催乳素细胞中，在一些鱼中，还存在于中间部一些含促性腺激素的细胞中，但不存在于远侧部的促性腺激素细胞中。在脑-垂体-性腺轴的成熟和运作过程中，结合单胺、神经肽和垂体激素之间的相互作用，讨论了ir-TH在与生殖系统调节相关的脑中枢和垂体细胞中的定位。
