Margolis-Nunno H, Halpern-Sebold L, Schreibman M P
Neurobiol Aging. 1986 Jan-Feb;7(1):17-21. doi: 10.1016/0197-4580(86)90021-7.
The immunocytochemical distribution of immunoreactive serotonin (ir-5HT) was studied in the forebrain of male platyfish ranging in age from 5 to 30 months (mean life span, 30 months). In fish at all ages, ir-5HT is found in the forebrain in the wall of the third ventricle and its lateral and posterior recesses and in the pituitary in PAS-positive cells of the pars intermedia (PI). With increasing age, ir-5HT first appears in perikarya of the nucleus preopticus (18 months) and in gonadotropes of the caudal pars distalis. Between 8 and 12 months of age, some fish display pale 5HT immunoreactivity in pituitary gonadotropes while in all fish of 18 months and older, the gonadotropes as well as the PI cells show intense 5HT immunostaining. It is suggested that these modifications in serotonin localization may be related to reproductive senescence in platyfish and that they may be associated with other age-related changes in neurohormone and neurotransmitter immunoreactivity. These results are compared with similar age-related changes in the metabolism of neurotransmitters which have been found in mammals.
研究了年龄在5至30个月（平均寿命30个月）的雄性剑尾鱼前脑中免疫反应性5-羟色胺（ir-5HT）的免疫细胞化学分布。在所有年龄段的鱼中，ir-5HT在前脑第三脑室壁及其外侧和后隐窝以及垂体中间部（PI）的PAS阳性细胞中均有发现。随着年龄的增长，ir-5HT首先出现在视前核的核周体（18个月）和尾侧远侧部的促性腺激素细胞中。在8至12个月龄之间，一些鱼的垂体促性腺激素细胞显示出淡的5HT免疫反应性，而在所有18个月及以上的鱼中，促性腺激素细胞以及PI细胞均显示出强烈的5HT免疫染色。提示5-羟色胺定位的这些变化可能与剑尾鱼的生殖衰老有关，并且可能与神经激素和神经递质免疫反应性的其他年龄相关变化有关。将这些结果与在哺乳动物中发现的神经递质代谢的类似年龄相关变化进行了比较。
