Faculty of Chemistry, VNUHCM-University of Science , 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City, Vietnam.
Cancer Research Laboratory, Vietnam National University, Ho Chi Minh City , 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City, Vietnam.
J Nat Prod. 2017 Jun 23;80(6):1876-1882. doi: 10.1021/acs.jnatprod.7b00171. Epub 2017 Jun 5.
From an EtOAc-soluble extract of the roots of Taxus wallichiana, six new (1-6) and 11 known lignans were isolated. The structures of the new compounds were elucidated based on interpretation of spectroscopic data. (+)-7'-epi-Tsugacetal (1) is a rare aryltetralin-type lignan having a cis-orientation of H-7' and H-8'. Compounds 3-6 were identified as the first naturally occurring tetrahydrofuranoid lignans having a cis-orientation of H-7 and H-8. All tested compounds were found to possess α-glucosidase inhibitory activity, with formosanol (9) showing the most potent effect with an IC value of 35.3 μM.
从红豆杉根的 EtOAc 可溶提取物中分离得到六个新的（1-6）和 11 个已知的木脂素。根据光谱数据分析，阐明了新化合物的结构。（+）-7'-epi-Tsugacetal（1）是一种罕见的芳基四氢呋喃型木脂素，具有 H-7'和 H-8'的顺式取向。化合物 3-6 被鉴定为具有 H-7 和 H-8 顺式取向的第一个天然存在的四氢呋喃型木脂素。所有测试的化合物都被发现具有α-葡萄糖苷酶抑制活性，其中 formosanol（9）的 IC 值为 35.3 μM，表现出最强的效果。
