Nguyen Thi Trang, Nguyen Duc Hung, Zhao Bing Tian, Le Duc Dat, Choi Du Hyung, Kim Young Ho, Nguyen Thi Hoai, Woo Mi Hee
College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongsan 38430, Republic of Korea; Buon Ma Thuot University, Buon Ma Thuot City, Dak Lak Province 630000, Viet Nam.
College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongsan 38430, Republic of Korea; Phutho College of Medicine and Pharmacy, Viettri City, Phutho Province 290000, Viet Nam.
Bioorg Chem. 2017 Oct;74:221-227. doi: 10.1016/j.bioorg.2017.08.007. Epub 2017 Aug 20.
A new lignan, utilisin (1), and a new alkaloid, echinoutilin (2), together with eleven known compounds 3-13 were isolated from the grains of Echinochloa utilis Ohwi & Yabuno. Their structures were identified through the analysis of spectroscopic data. The absolute configuration of 2 was determined by Mosher's method. These compounds were evaluated for α-glucosidase inhibitory activity. Among them, compounds 2, 3 and 6 exhibited considerable α-glucosidase inhibitory activity with IC values of 42.1±1.3, 58.9±3.7, and 40.9±1.1μM, respectively. The results indicate that the grains of E. utilis will be useful in the treatment of diabetes control agents.
从稗子（Echinochloa utilis Ohwi & Yabuno）的谷粒中分离出一种新的木脂素——utilisin（1）和一种新的生物碱——echinoutilin（2），以及11种已知化合物3 - 13。通过光谱数据分析确定了它们的结构。2的绝对构型通过Mosher方法确定。对这些化合物进行了α - 葡萄糖苷酶抑制活性评估。其中，化合物2、3和6表现出相当强的α - 葡萄糖苷酶抑制活性，IC值分别为42.1±1.3、58.9±3.7和40.9±1.1μM。结果表明，稗子的谷粒在糖尿病控制剂的治疗中具有应用价值。
