Doi Takehiko, Shimada Hiroyuki, Makizako Hyuma, Tsutsumimoto Kota, Verghese Joe, Suzuki Takao
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Japan Society for the Promotion of Science, Tokyo, Japan.
J Alzheimers Dis. 2017;59(1):77-84. doi: 10.3233/JAD-170195.
It is important to examine the etiology of motoric cognitive risk syndrome (MCR) and its association with dementia and disability to obtain biological insights and to develop preventive strategies.
This study aimed to examine the association of MCR with incidence of dementia and disability in a Japanese community-dwelling sample of older adults.
Participants were 4,235 older adults (50% women, mean age: 72.0 years). MCR was diagnosed at baseline using established criteria in non-demented seniors with self-reported cognitive complaints and slow gait. Incident cases of dementia were identified from insurance data monthly. Disability was regarded as certification by long-term care insurance.
At baseline, 265 participants (6.3%) met criteria for MCR. During follow-up (mean duration: 29 months), there were 138 incident cases of dementia (3.3%) and 207 incident cases of disability (4.9%). Cox-proportional hazards models, adjusted for demographical data, lifestyle, and medical conditions, showed that presence of MCR at baseline was a major risk factor for developing dementia (HR 2.49, 95% CI 1.52-4.10, p < 0.001). MCR also predicted risk for disability (HR 1.69, 95% CI 1.08-2.02, p < 0.001).
MCR is helpful in the short-term prediction of risk for dementia and disability in the elderly Japanese population. Identification of seniors with MCR is recommended for early detection and instituting preventive measures for reducing the risk of dementia and disability.
研究运动认知风险综合征（MCR）的病因及其与痴呆和残疾的关联，对于获得生物学见解和制定预防策略至关重要。
本研究旨在调查日本社区居住的老年人群样本中MCR与痴呆和残疾发生率之间的关联。
参与者为4235名老年人（50%为女性，平均年龄：72.0岁）。在基线时，根据既定标准对自我报告有认知主诉且步态缓慢的非痴呆老年人进行MCR诊断。每月从保险数据中识别痴呆的发病病例。残疾被视为长期护理保险的认证。
在基线时，265名参与者（6.3%）符合MCR标准。在随访期间（平均持续时间：29个月），有138例痴呆发病病例（3.3%）和207例残疾发病病例（4.9%）。经人口统计学数据、生活方式和医疗状况调整后的Cox比例风险模型显示，基线时存在MCR是发生痴呆的主要危险因素（风险比[HR] 2.49，95%置信区间[CI] 1.52 - 4.10，p < 0.001）。MCR还可预测残疾风险（HR 1.69，95% CI 1.08 - 2.02，p < 0.001）。
MCR有助于对日本老年人群痴呆和残疾风险进行短期预测。建议识别患有MCR的老年人，以便早期发现并采取预防措施降低痴呆和残疾风险。
