老年人呼气峰值流量与运动认知风险综合征的关联。
Association of peak expiratory flow with motoric cognitive risk syndrome among older adults.
作者信息
Xu Hui, Gong Xiangwen, Cui Kaiwang, Li Xuerui, Chen Long, Lu Yiyi, Liao Yangfang, Liu Jianping
机构信息
Big Data Center, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, China.
Department of Respiratory and Critical Care Medicine, Ganzhou Key Laboratory of Respiratory Diseases, Ganzhou Institute of Respiratory Diseases, The Fifth People's Hospital of Ganzhou, Ganzhou, Jiangxi, China.
出版信息
Front Aging Neurosci. 2024 Aug 7;16:1412542. doi: 10.3389/fnagi.2024.1412542. eCollection 2024.
BACKGROUND
The association between lung function and motoric cognitive risk syndrome (MCR) is unclear. We aimed to explore the association of peak expiratory flow (PEF) with MCR using cross-sectional and longitudinal analyses.
METHODS
Within the CHARLS, 5095 participants were included in the cross-sectional analysis, and 4340 MCR-free participants were included in the longitudinal analysis. The PEF was assessed with a lung peak flow meter. MCR was characterized by cognitive complaints and a slow walking speed with normal mobility and without dementia. Logistic regression, Cox regression, and Laplace regression models were employed for data analysis.
RESULTS
In this cross-sectional study, logistic regression analyses revealed that continuous PEF was associated with MCR (odds ratio [OR], 0.998; 95% confidence interval [CI], 0.998, 0.999), and the ORs (95% CIs) of MCR prevalence were 0.857 (0.693, 1.061) for the middle tertile and 0.665 (0.524, 0.845) for the highest tertile compared to the lowest tertile. In a longitudinal cohort study, continuous PEF was dose-dependently associated with the risk of MCR. Compared with those in the lowest tertile of PEF, the hazard ratios (95% CIs) of incident MCR were 0.827 (0.661, 1,036) for the middle tertile and 0.576 (0.432, 0.767) for the highest tertile. Furthermore, compared with the lowest tertile, the highest tertile was associated with a delayed onset time of MCR of 0.484 (95% CI: 0.151, 0.817) years.
CONCLUSION
A higher PEF was related to a lower prevalence of MCR and a lower risk for MCR, and a higher PEF also prolonged the onset time of MCR.
背景
肺功能与运动认知风险综合征（MCR）之间的关联尚不清楚。我们旨在通过横断面和纵向分析探讨呼气峰值流速（PEF）与MCR的关联。
方法
在“中国健康与养老追踪调查”（CHARLS）中，5095名参与者纳入横断面分析，4340名无MCR的参与者纳入纵向分析。使用肺峰值流量计评估PEF。MCR的特征为认知主诉、行走速度缓慢、活动能力正常且无痴呆。采用逻辑回归、Cox回归和拉普拉斯回归模型进行数据分析。
结果
在这项横断面研究中，逻辑回归分析显示，连续PEF与MCR相关（比值比[OR]，0.998；95%置信区间[CI]，0.998，0.999），与最低三分位数相比，MCR患病率的OR（95%CI）在中间三分位数为0.857（0.693，1.061），在最高三分位数为0.665（0.524，0.845）。在纵向队列研究中，连续PEF与MCR风险呈剂量依赖性相关。与PEF最低三分位数的参与者相比，中间三分位数发生MCR的风险比（95%CI）为0.827（0.661，1.036），最高三分位数为0.576（0.432，0.767）。此外，与最低三分位数相比，最高三分位数与MCR发病时间延迟0.484年（95%CI：0.151，0.817）相关。
结论
较高的PEF与较低的MCR患病率和较低的MCR风险相关，且较高的PEF还可延长MCR的发病时间。
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