Xing Yiwen, Zhang Li, Liu Pan, Pan Yiming, Tang Zhe, Ma Lina
Department of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Medicine, Beijing 100053, China.
Beijing Geriatric Healthcare Center, Xuanwu Hospital Capital Medical University, Beijing Institute of Geriatrics, Beijing 100053, China.
J Nutr Health Aging. 2025 May 14;29(7):100578. doi: 10.1016/j.jnha.2025.100578.
Motoric cognitive risk syndrome (MCR) is a pre-dementia syndrome characterized by slow gait and subjective cognitive decline, increasing the risk of adverse clinical events such as dementia and falls in older adults. However, whether self-reported MCR (sMCR) predicts long-term mortality in Chinese older adults remains unknown. This study aimed to explore the role of sMCR in 8-year mortality in community-dwelling older adults.
Longitudinal cohort study.
Data were sourced from the Beijing Longitudinal Study of Aging.
A total of 1,683 community-dwelling individuals aged 65 years and older who were free from disability and dementia at baseline were included.
sMCR was defined based on the presence of subjective cognitive decline and self-reported slow gait. Mortality data were tracked over the 8-year follow-up period. Cox regression models were used to analyze the association between sMCR and 8-year mortality.
A total of 113 (6.71%) community-dwelling individuals had sMCR. sMCR was associated with female sex, older age, no spouse, living in rural areas, low education level, low monthly income, no work, no tea intake, poor sleep quality, inactivity, poor physical performance, chronic diseases, and frailty. Participants with sMCR had a higher 8-year mortality compared to those without (70.80% vs. 34.52%). Cox regression analysis showed that sMCR predicted 8-year mortality (hazard ratio [HR] = 2.859, 95% confidence interval [CI] 2.260-3.619). This association remained significant even after adjusting for sex, age, area, education level, marital status, chronic diseases, and lifestyle factors (HR = 1.540, 95% CI 1.169-2.028).
sMCR is a predictor of 8-year mortality in Chinese community-dwelling older adults, which highlights the importance of early identification and intervention for sMCR to reduce adverse clinical outcomes in the aging population.
运动认知风险综合征（MCR）是一种痴呆前综合征，其特征为步态缓慢和主观认知能力下降，会增加老年人患痴呆和跌倒等不良临床事件的风险。然而，自我报告的MCR（sMCR）是否能预测中国老年人的长期死亡率尚不清楚。本研究旨在探讨sMCR在社区居住老年人8年死亡率中的作用。
纵向队列研究。
数据来源于北京老龄化纵向研究。
共纳入1683名65岁及以上的社区居住个体，他们在基线时无残疾和痴呆。
sMCR根据主观认知能力下降和自我报告的步态缓慢来定义。在8年的随访期内跟踪死亡率数据。采用Cox回归模型分析sMCR与8年死亡率之间的关联。
共有113名（6.71%）社区居住个体患有sMCR。sMCR与女性、高龄、无配偶、居住在农村地区、教育水平低、月收入低、无工作、不喝茶、睡眠质量差、缺乏运动、身体机能差、慢性病和虚弱有关。与未患sMCR的参与者相比，患sMCR的参与者8年死亡率更高（70.80%对34.52%）。Cox回归分析表明，sMCR可预测8年死亡率（风险比[HR]=2.859，95%置信区间[CI]2.260 - 3.619）。即使在调整了性别、年龄、地区、教育水平、婚姻状况、慢性病和生活方式因素后，这种关联仍然显著（HR = 1.540，95% CI 1.169 - 2.028）。
sMCR是中国社区居住老年人8年死亡率的一个预测指标，这凸显了早期识别和干预sMCR以减少老年人群不良临床结局的重要性。
