Sinz Hannah, Renz Harald, Skevaki Chrysanthi
Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, University Hospital Giessen and Marburg GmbH Baldingerstr, Marburg, Germany.
Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, University Hospital Giessen and Marburg GmbH Baldingerstr, Marburg, Germany.
Ann Allergy Asthma Immunol. 2017 Jun;118(6):672-679. doi: 10.1016/j.anai.2017.04.016.
To provide an overview of studied cellular and noncellular blood-derived asthma biomarkers.
PubMed literature review.
Articles discussing cellular and noncellular bloodborne asthma biomarkers.
Discussed asthma biomarkers include peripheral blood cell counts of T cells, fibrocytes, or granulocytes, as well as levels of cytokines, periostin, IgE, and lipid mediators with or without stimulation. Moreover, this article summarizes the association of various blood biomarkers with the type of airway inflammation, presence of atopy, and dominance of specific T-cell subsets and associated pathways in asthma. Furthermore, biomarkers are here listed according to their proposed clinical use, such as diagnosis, disease phenotyping, classification of severity, assessment of disease control, and monitoring of and predicting treatment response.
Further research on asthma biomarkers may improve asthma endotyping and ultimately lead to personalized treatment.
概述已研究的细胞和非细胞血液来源的哮喘生物标志物。
PubMed文献综述。
讨论细胞和非细胞血源性哮喘生物标志物的文章。
所讨论的哮喘生物标志物包括T细胞、纤维细胞或粒细胞的外周血细胞计数，以及细胞因子、骨膜蛋白、免疫球蛋白E（IgE）和脂质介质在有或无刺激情况下的水平。此外，本文总结了各种血液生物标志物与气道炎症类型、特应性的存在、特定T细胞亚群的优势以及哮喘相关途径之间的关联。此外，根据生物标志物的临床应用，如诊断、疾病表型分析、严重程度分类、疾病控制评估以及治疗反应的监测和预测，在此列出了生物标志物。
对哮喘生物标志物的进一步研究可能会改善哮喘的内型分类，并最终实现个性化治疗。
