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苹果螺中特定神经元的乙酰胆碱反应——I. 乙酰胆碱诱导的膜电导与电位依赖性膜电导之间的相互作用

Acetylcholine responses of identified neurons in Helix pomatia--I. Interactions between acetylcholine-induced and potential-dependent membrane conductances.

作者信息

Witte O W, Speckmann E J, Walden J

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;80(1):15-23. doi: 10.1016/0742-8413(85)90127-6.

DOI:10.1016/0742-8413(85)90127-6
PMID:2858336
Abstract

The influence of potential-dependent membrane conductances on amplitude and time course of acetylcholine (ACh) responses was studied. The investigations were performed on the identified neurons B1 and B3 of the buccal ganglion of Helix pomatia. The neurons B1 and B3 were depolarized by ACh. The depolarization was accompanied by a decrease of membrane resistance. An inward rectification occurring negative to the resting membrane potential (RMP) reduced the amplitude of the ACh depolarizations. An outward rectification occurring positive to the RMP consisted of two parts and ceiled the ACh responses. The early outward current reduced the amplitude and modified the time course of ACh responses. Local responses or axonal action potentials increased the amplitude of the ACh depolarizations.

摘要

研究了电位依赖性膜电导对乙酰胆碱(ACh)反应幅度和时程的影响。研究在苹果螺颊神经节中已鉴定的神经元B1和B3上进行。神经元B1和B3被ACh去极化。去极化伴随着膜电阻的降低。在静息膜电位(RMP)负值时出现的内向整流降低了ACh去极化的幅度。在RMP正值时出现的外向整流由两部分组成,限制了ACh反应。早期外向电流降低了ACh反应的幅度并改变了其时程。局部反应或轴突动作电位增加了ACh去极化的幅度。

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