Mazon Janaína Niero, de Mello Aline Haas, Ferreira Gabriela Kozuchovski, Rezin Gislaine Tezza
Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Av. José Acácio Moreira, 787, 88704-900 Tubarão, SC, Brazil.
Laboratory Pharmacology and Pathophysiology of Skin, Department of Pharmacology, Federal University of Paraná, Av. Coronel Franscisco Heráclito dos Santos, 210, 81531-970 Curitiba, PR, Brazil.
Life Sci. 2017 Aug 1;182:22-28. doi: 10.1016/j.lfs.2017.06.002. Epub 2017 Jun 3.
Neurodegenerative diseases are a growing health concern. The increasing incidences of these disorders have a great impact on the patients' quality of life. Although the mechanisms of neurodegenerative diseases are still far from being clarified, several studies look for new discoveries about their pathophysiology and prevention. Furthermore, evidence has shown a strong correlation between obesity and the development of Alzheimer's disease (AD) and Parkinson's disease (PD). Metabolic changes caused by overweight are related to damage to the central nervous system (CNS), which can lead to neural death, either by apoptosis or cell necrosis, as well as alter the synaptic plasticity of the neuron. This review aims to show the association between neurodegenerative diseases, focusing on AD and PD, and metabolic alterations.
神经退行性疾病正日益引起人们对健康的关注。这些疾病发病率的不断上升对患者的生活质量产生了巨大影响。尽管神经退行性疾病的发病机制仍远未阐明，但一些研究正在寻找有关其病理生理学和预防方面的新发现。此外，有证据表明肥胖与阿尔茨海默病（AD）和帕金森病（PD）的发生发展之间存在密切关联。超重引起的代谢变化与中枢神经系统（CNS）损伤有关，这可能导致神经细胞死亡，无论是通过凋亡还是细胞坏死，还会改变神经元的突触可塑性。本综述旨在阐述神经退行性疾病（重点是AD和PD）与代谢改变之间的关联。
