Chaksari Hadiseh Rahimi, Ebrahimi Pouya, Yavari Tahereh, Sharifi Farshad, Ramezai Pedram, Pirdehghan Reza, Naderi Fatemeh, Moodi Mitra, Khorashadizadeh Masoumeh, Payab Moloud, Pour Mahbube Ebrahim
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Cardiovascular Disease Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Aging Clin Exp Res. 2025 Jun 28;37(1):201. doi: 10.1007/s40520-025-03092-7.
Dynapenic abdominal obesity (DAO) is the coexistence of obesity and dynapenia, defined as muscle weakness. Both abdominal obesity and dynapenia may contribute to falls in older adults. This study assesses the relationship between DAO and the risk of falls in the population ≥ over 60 who participated in the Birjand Longitudinal Aged Study (BLAS) trial.
This prospective cohort study involves 1,418 elderly participants aged ≥ 60. The sample, representative of the aged population BLAS program, was selected using stratified random cluster sampling. Data on fall events - including the date, time, cause, and associated injuries - were collected through a structured researcher-designed data collection form via telephone contact with the participants or their families. Clinical examination findings and paraclinical test results per the study protocol were also available to researchers.
Of the 1,418 participants, 697 (51.71%) were women, and 651 (48.29%) were men, with a mean age of 69.73. The presence of DAO was significantly associated with a higher risk of falls, with a coefficient of OR = 2.65 (CI 95% 1.03-6.84, P = 0.044). Among the participants, 757(56.2%), 422 (31.3%), and 169 (12.5%) fell in the age groups between 60 and 69, 70-79, and ≥ 80 years, respectively. Male gender (OR: 0.45, 95%CI: 0.23-0.90, P-value: 0.23), on the other hand, was linked to a lower risk of falls, and this association was statistically significant. Furthermore, a higher risk of falls was observed among those with higher scores on the "Time to Get Up and Go" test (OR: 1.80, 95%CI: 1.11-2.92, P-value: 0.16), as well as those with depression (OR: 2.13, 95%CI: 1.30-3.49, P-value: 0.003), and anemia (OR: 1.89, 95%CI: 1.02-3.50, P-value: 0.043), with coefficients of 0.59, 0.75, and 0.63, respectively, all of which were statistically significant.
This study's findings suggest that DAO is a significant risk factor for falls in elderly individuals. Moreover, the male gender appears to be protected against falls. In contrast, factors such as depression, higher risk based on the Time to "Get Up and go" test, and anemia are associated with elevated risk. These factors may be crucial in understanding the relationship between Dynapenic abdominal obesity and fall risk in the elderly. They can help stratify aged adults to prevent falls more efficiently.
Not applicable.
肌无力性腹型肥胖（DAO）是肥胖与肌无力（定义为肌肉力量减弱）并存的情况。腹型肥胖和肌无力都可能导致老年人跌倒。本研究评估了参与比尔詹德纵向老年研究（BLAS）试验的60岁及以上人群中DAO与跌倒风险之间的关系。
这项前瞻性队列研究涉及1418名年龄≥60岁的老年参与者。该样本采用分层随机整群抽样方法选取，代表了BLAS项目中的老年人群。通过研究人员设计的结构化数据收集表，通过电话联系参与者或其家人，收集跌倒事件的数据，包括日期、时间、原因和相关损伤。研究方案中的临床检查结果和辅助检查结果也可供研究人员使用。
在1418名参与者中，697名（51.71%）为女性，651名（48.29%）为男性，平均年龄为69.73岁。DAO的存在与跌倒风险显著相关，OR系数为2.65（95%CI 1.03 - 6.84，P = 0.044）。在参与者中，60至69岁、70至79岁和80岁及以上年龄组中，分别有757名（56.2%）、422名（31.3%）和169名（12.5%）参与者跌倒。另一方面，男性（OR：0.45，95%CI：0.23 - 0.90，P值：0.23）与较低的跌倒风险相关，且这种关联具有统计学意义。此外，在“起身行走时间”测试中得分较高的人（OR：1.80，95%CI：1.11 - 2.92，P值：0.16）、患有抑郁症的人（OR：2.13，95%CI：1.30 - 3.49，P值：0.003）和贫血患者（OR：1.89，95%CI：1.02 - 3.50，P值：0.043）中，跌倒风险较高，系数分别为0.59、0.75和0.63，所有这些均具有统计学意义。
本研究结果表明，DAO是老年人跌倒的一个重要危险因素。此外，男性似乎不易跌倒。相比之下，抑郁症、基于“起身行走时间”测试的较高风险以及贫血等因素与跌倒风险升高相关。这些因素对于理解肌无力性腹型肥胖与老年人跌倒风险之间的关系可能至关重要。它们有助于对老年人进行分层，以更有效地预防跌倒。
不适用。
