Yosselson-Superstine S, Lipman A G, Sanders S H
Isr J Med Sci. 1985 Feb;21(2):113-7.
We examined the relative clinical efficacy of three commonly used antianxiety medications and a placebo as adjuncts to analgesic treatment of chronic cancer and arthritic pain. Nine patients with chronic pain, including six with malignancy and three with rheumatic diseases, were each exposed to three treatment phases with antianxiety drugs (hydroxyzine, prochlorperazine, and chlordiazepoxide) and one placebo phase in a double-blind, counter-balanced design. Each phase lasted 2 weeks, with analgesic medication given throughout. Pre- and post-phase measures of anxiety, depression, and hostility were taken, together with daily reports by the patients on pain, mood, and medication intake. None of the antianxiety drugs were significantly more effective than the placebo in reducing pain levels, daily medication usage or hostility. Chlordiazepoxide significantly reduced anxiety and depression compared with the placebo, but also produced the most side effects (e.g., drowsiness). The preliminary findings failed to support the efficacy of the three antianxiety medications as analgesic adjuncts.
我们研究了三种常用抗焦虑药物及一种安慰剂作为慢性癌症和关节炎疼痛镇痛治疗辅助药物的相对临床疗效。九名慢性疼痛患者，其中六名患有恶性肿瘤，三名患有风湿性疾病，在双盲、平衡设计中，每人接受三个使用抗焦虑药物（羟嗪、氯丙嗪和氯氮卓）的治疗阶段和一个安慰剂阶段。每个阶段持续2周，全程给予镇痛药物。在每个阶段前后测量焦虑、抑郁和敌意程度，并让患者每日报告疼痛、情绪和药物摄入情况。在降低疼痛程度、每日药物使用量或敌意方面，没有一种抗焦虑药物比安慰剂更有效。与安慰剂相比，氯氮卓显著降低了焦虑和抑郁，但也产生了最多的副作用（如嗜睡）。初步研究结果未能支持这三种抗焦虑药物作为镇痛辅助药物的疗效。
