School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M15GD, UK.
Baylor College of Medicine, Houston, TX, USA.
Osteoporos Int. 2017 Sep;28(9):2683-2689. doi: 10.1007/s00198-017-4104-2. Epub 2017 Jun 5.
Bone mineral density declines with increasing older age. We examined the levels of circulating factors known to regulate bone metabolism in healthy young and older adults. The circulating levels of dickkopf-1, osteocalcin, osteoprotegerin and sclerostin were positively associated with whole-body bone mineral density (WBMD) in older adults, despite the average WBMD being lower and circulating dickkopf-1, osteoprotegerin and sclerostin being higher in old than young.
This study aims to investigate the relationship between whole-body bone mineral density (WBMD) and levels of circulating factors with known roles in bone remodelling during 'healthy' ageing.
WBMD and fasting plasma concentrations of dickkopf-1, fibroblast growth factor-23, osteocalcin, osteoprotegerin, osteopontin and sclerostin were measured in 272 older subjects (69 to 81 years; 52% female) and 171 younger subjects (18-30 years; 53% female).
WBMD was lower in old than young. Circulating osteocalcin was lower in old compared with young, while dickkopf-1, osteoprotegerin and sclerostin were higher in old compared with young. These circulating factors were each positively associated with WBMD in the older adults and the relationships remained after adjustment for covariates (r values ranging from 0.174 to 0.254, all p < 0.01). In multivariate regression, the body mass index, circulating sclerostin and whole-body lean mass together accounted for 13.8% of the variation with WBMD in the older adults. In young adults, dickkopf-1 and body mass index together accounted for 7.7% of variation in WBMD.
Circulating levels of dickkopf-1, osteocalcin, osteoprotegerin and sclerostin are positively associated with WBMD in community-dwelling older adults, despite the average WBMD being lower and circulating dickkopf-1, osteoprotegerin and sclerostin being higher in old than young.
骨密度随年龄增长而下降。我们检查了已知调节骨代谢的循环因子水平在健康的年轻和老年成年人中。循环骨钙素、骨保护素和硬化素水平与老年人的全身骨密度（WBMD）呈正相关，尽管老年人的平均 WBMD 较低，循环骨钙素、骨保护素和硬化素水平较高。
本研究旨在探讨全身骨密度（WBMD）与已知在“健康”衰老过程中具有骨重塑作用的循环因子水平之间的关系。
在 272 名老年受试者（69-81 岁；52%为女性）和 171 名年轻受试者（18-30 岁；53%为女性）中测量了 WBMD 和空腹血浆中 dickkopf-1、成纤维细胞生长因子 23、骨钙素、骨保护素、骨桥蛋白和硬化素的浓度。
WBMD 在老年人中低于年轻人。与年轻人相比，老年人的循环骨钙素水平较低，而 dickkopf-1、骨保护素和硬化素水平较高。这些循环因子在老年人中均与 WBMD 呈正相关，并且在调整协变量后，这些关系仍然存在（r 值范围为 0.174 至 0.254，所有 p 值均<0.01）。在多元回归中，体质指数、循环硬化素和全身瘦体重共同解释了老年人 WBMD 变异的 13.8%。在年轻成年人中，dickkopf-1 和体质指数共同解释了 WBMD 变异的 7.7%。
尽管老年人的平均 WBMD 较低，循环 dickkopf-1、骨保护素和硬化素水平较高，但循环 dickkopf-1、骨钙素、骨保护素和硬化素水平与社区居住的老年成年人的 WBMD 呈正相关。
