Laboratory of Companion Animal Surgery, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.
Open Vet J. 2022 Nov-Dec;12(6):980-984. doi: 10.5455/OVJ.2022.v12.i6.26. Epub 2022 Dec 15.
Gerontology is a major research topic in veterinary medicine; however, there are few reports on changes in biomarker levels in aged dogs.
The purpose of this preliminary study was to evaluate the differences in serum biomarker levels between young (less than 36 months) and old (over 108 months) companion dogs.
We measured the serum concentrations of brain-derived neurotrophic factor (BDNF), osteoprotegerin (OPG), angiotensin II (ANGII), and endothelin-1 (ET-1) in both groups (young: = 16, 19.8 ± 9.3 months old; old: = 16, 155.8 ± 22.8 months old).
Although the concentrations of BDNF did not differ between the two groups, the OPG, ANGII, and ET-1 levels were significantly higher in the old companion dogs than in the young dogs ( < 0.05).
OPG, ANGII, and ET-1 concentrations may increase in dogs during aging.
老年医学是兽医领域的一个主要研究课题；然而，关于老年犬生物标志物水平变化的报道很少。
本初步研究旨在评估年轻（<36 个月）和老年（>108 个月）伴侣犬之间血清生物标志物水平的差异。
我们测量了两组（年轻组：n=16，19.8±9.3 个月；老年组：n=16，155.8±22.8 个月）血清中脑源性神经营养因子（BDNF）、骨保护素（OPG）、血管紧张素 II（ANGII）和内皮素-1（ET-1）的浓度。
尽管两组间 BDNF 浓度无差异，但老年犬的 OPG、ANGII 和 ET-1 水平明显高于年轻犬（<0.05）。
OPG、ANGII 和 ET-1 浓度可能在犬衰老过程中增加。
