Liu Yunru, Yu Dee, Xiao Sha
Hainan Medical University, China.
J Pak Med Assoc. 2017 Jun;67(6):933-935.
Formaldehyde (FA) is the major volatile organic chemical (VOC) present in indoor air, and a constituent known to be associated with sick building syndrome. In the present study, mice were exposed to different concentrations of FA (0, 1, 10 mg/ m3) through static inhalation for 2 hours per day for 20 weeks. The polychromatic erythrocytes/ normochromatic erythrocyte (PCE/NCE) ratio and the micronucleus rates in bone marrow cells were detected. Data indicated that the PCE/NCE ratio in two FA exposure groups were statistically significant lower than the negative control group (P <0.05), and the micronucleus rate in two FA exposure groups were not significantly higher than the control group (P>0.05). These results suggest that chronic static inhalation of FA can reduce the ratio of PCE/NCE in the mice bone marrow, but the effects to the mice bone micronucleus rate are not sure.
甲醛（FA）是室内空气中存在的主要挥发性有机化合物（VOC），是一种已知与病态建筑综合症相关的成分。在本研究中，小鼠每天通过静态吸入暴露于不同浓度的FA（0、1、10毫克/立方米），每天2小时，持续20周。检测骨髓细胞中的多色红细胞/正色红细胞（PCE/NCE）比率和微核率。数据表明，两个FA暴露组的PCE/NCE比率均显著低于阴性对照组（P<0.05），两个FA暴露组的微核率均未显著高于对照组（P>0.05）。这些结果表明，长期静态吸入FA可降低小鼠骨髓中PCE/NCE的比率，但对小鼠骨髓微核率的影响尚不确定。
