中国广西一株新型HIV-1 CRF01_AE/CRF07_BC重组病毒的特征分析
Characterization of a New HIV-1 CRF01_AE/CRF07_BC Recombinant Virus in Guangxi, China.
作者信息
Kong Desheng, Wang Yan, Wang Chen, Liang Shujia, Feng Yi, Ruan Yuhua, Shao Yiming, Ma Liying
机构信息
1 State Key Laboratory of Infectious Disease Prevention and Control, Division of Virology and Immunology, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
2 Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University , Beijing, People's Republic of China .
出版信息
AIDS Res Hum Retroviruses. 2017 Nov;33(11):1166-1170. doi: 10.1089/AID.2017.0101. Epub 2017 Jul 10.
Currently, more and more kinds of circulating recombinant forms (CRFs) and unique recombinant forms (URFs) were identified in China. A novel second-generation CCR5-tropic HIV-1 recombinant virus (GX2016EU09) was identified here, which was isolated from a HIV-1-infected man who had sex with men (MSM) in Guangxi, China. Phylogenetic analysis of near full-length genome (NFLG) showed that the novel HIV-1 recombinant GX2016EU09 clustered with CRF01_AE reference sequences, but set up a distinct branch. Recombinant analysis showed that the NFLG of GX2016EU09 composed of CRF01_AE (as the backbone) and CRF07_BC, with nine recombination break points observed in the gag, pol, vif, vpr, tat, rev, vpu, env, and nef regions. To our knowledge, this HIV-1 URF differs from previously documented CRF01_AE/CRF07_BC forms. The emergence of a novel CRF01_AE/CRF07_BC recombinant strain indicates the increasing complexity of the HIV-1 epidemic among the MSM group in Guangxi, China.
目前，中国发现了越来越多种类的循环重组型（CRF）和独特重组型（URF）。在此鉴定出一种新型的第二代CCR5嗜性HIV-1重组病毒（GX2016EU09），它是从中国广西一名与男性发生性行为的HIV-1感染男性（男男性行为者）中分离出来的。近全长基因组（NFLG）的系统发育分析表明，新型HIV-1重组体GX2016EU09与CRF01_AE参考序列聚类，但形成了一个独特的分支。重组分析显示，GX2016EU09的NFLG由CRF01_AE（作为主干）和CRF07_BC组成，在gag、pol、vif、vpr、tat、rev、vpu、env和nef区域观察到9个重组断点。据我们所知，这种HIV-1 URF与先前记录的CRF01_AE/CRF07_BC形式不同。一种新型CRF01_AE/CRF07_BC重组毒株的出现表明中国广西男男性行为者群体中HIV-1流行的复杂性在增加。
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