Liu Meiliang, Chen Huanhuan, Li Jianjun, Cai Wenlong, Xie Haomin, Lan Guanghua, Zeng Xiaoyun
Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
Guangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and Prevention, Nanning, China.
AIDS Res Hum Retroviruses. 2023 Oct;39(10):567-574. doi: 10.1089/AID.2023.0043. Epub 2023 Aug 22.
CRF01_AE and CRF07_BC are the two predominant HIV-1 subtypes currently circulating in China. We identified here a novel CCR5-tropic HIV-1 second-generation recombinant form virus found in two individuals, (GX19017 and GX19032), which were isolated from two HIV-1-positive people in Guangxi, southwest China. Phylogenic analyses indicated that these two sequences were all composed of two well-established circulating recombinant forms (CRFs) CRF07_BC and CRF01_AE, with four recombinant breakpoints observed in the , /, and gene regions, respectively. The recombinant CRF01_AE region was clustered with the previously described CRF01_AE subcluster 2 lineage, which was characterized by the susceptibility to phenotypic transfer. The genome structure is significantly different from other previously reported CRFs and unique recombination forms. The emergence of a series of novel recombinant strains is indicative of the burgeoning complexity of the HIV-1 epidemic among the sexually transmitted population. Meanwhile, it may furnish significant insights into the dynamics and intricacy of the HIV-1 epidemic in China.
CRF01_AE和CRF07_BC是目前在中国流行的两种主要HIV-1亚型。我们在此鉴定出一种新型的CCR5嗜性HIV-1第二代重组形式病毒，该病毒在两名个体（GX19017和GX19032）中被发现，这两名个体是从中国西南部广西的两名HIV-1阳性者中分离出来的。系统发育分析表明，这两个序列均由两种成熟的循环重组形式（CRF）CRF07_BC和CRF01_AE组成，分别在、/和基因区域观察到四个重组断点。重组的CRF01_AE区域与先前描述的CRF01_AE亚簇2谱系聚类，其特征是对表型转移敏感。该基因组结构与其他先前报道的CRF和独特重组形式显著不同。一系列新型重组毒株的出现表明性传播人群中HIV-1流行的复杂性正在迅速增加。同时，它可能为中国HIV-1流行的动态和复杂性提供重要见解。
