R 型分泌蛋白不仅仅是 Wnt 的配角。
R-spondin Is More Than Just Wnt's Sidekick.
机构信息
Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands; Cancer Genomics Netherlands, Academic Medical Center, the Netherlands.
Cancer Research UK Beatson Institute, Glasgow, Scotland; Institute of Cancer Sciences, University Of Glasgow, Glasgow, Scotland.
出版信息
Dev Cell. 2017 Jun 5;41(5):456-458. doi: 10.1016/j.devcel.2017.05.018.
The intestinal crypt and its stem cells are dependent on the Wnt pathway. Reporting in Nature, Yan et al. (2017) show that Wnts and Wnt signaling potentiator R-spondins have non-interchangeable roles. Both are necessary for intestinal stem cell (ISC) maintenance, and R-spondins are the limiting factor that defines ISC number.
肠隐窝及其干细胞依赖于 Wnt 途径。Yan 等人在《自然》杂志上的报告（2017 年）表明，Wnt 及其信号增强子 R 应答蛋白具有不可互换的作用。两者对于肠干细胞（ISC）的维持都是必需的，而 R 应答蛋白是决定 ISC 数量的限制因素。
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