Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands; Cancer Genomics Netherlands, Academic Medical Center, the Netherlands.
Cancer Research UK Beatson Institute, Glasgow, Scotland; Institute of Cancer Sciences, University Of Glasgow, Glasgow, Scotland.
Dev Cell. 2017 Jun 5;41(5):456-458. doi: 10.1016/j.devcel.2017.05.018.
The intestinal crypt and its stem cells are dependent on the Wnt pathway. Reporting in Nature, Yan et al. (2017) show that Wnts and Wnt signaling potentiator R-spondins have non-interchangeable roles. Both are necessary for intestinal stem cell (ISC) maintenance, and R-spondins are the limiting factor that defines ISC number.
肠隐窝及其干细胞依赖于 Wnt 途径。Yan 等人在《自然》杂志上的报告（2017 年）表明，Wnt 及其信号增强子 R 应答蛋白具有不可互换的作用。两者对于肠干细胞（ISC）的维持都是必需的，而 R 应答蛋白是决定 ISC 数量的限制因素。
