Fleck A, Raines G, Hawker F, Trotter J, Wallace P I, Ledingham I M, Calman K C
Lancet. 1985 Apr 6;1(8432):781-4. doi: 10.1016/s0140-6736(85)91447-3.
The rate of loss of albumin to the tissue spaces (measured as transcapillary escape rate) rose by more than 300% in patients with septic shock, and the average increase within 7 h of cardiac surgery was 100%. The transcapillary escape rate in cachectic cancer patients was twice that of a group of healthy individuals. The rate of loss of albumin to the tissue spaces is normally 5%/h, which is more than 10 times the rates of synthesis and catabolism, and these large rate increases indicate that increased vascular permeability is an important cause of the lowered concentration of albumin commonly seen in acute and chronic disease.
在感染性休克患者中，白蛋白向组织间隙的丢失率（以毛细血管超滤率衡量）增加了300%以上，心脏手术后7小时内的平均增加率为100%。恶病质癌症患者的毛细血管超滤率是一组健康个体的两倍。白蛋白向组织间隙的正常丢失率为5%/小时，这是合成和分解代谢率的10倍以上，这些大幅增加表明血管通透性增加是急慢性疾病中常见的白蛋白浓度降低的重要原因。
