改善结直肠癌患者的治疗效果：患者报告结局的作用——一份欧洲消化道肿瘤学会（ESDO）报告
Improving Outcomes in Patients with CRC: The Role of Patient Reported Outcomes-An ESDO Report.
作者信息
Van Cutsem Eric, De Gramont Aimery, Henning Geoffrey, Rougier Philippe, Bonnetain Franck, Seufferlein Thomas
机构信息
Department of Digestive Oncology, University Hospitals Gasthuisberg, and KU Leuven, 493000 Leuven, Belgium.
Service d'Oncologie Médicale/Oncology Department, Institut hospitalier Franco-Britannique/Franco-British Institute, 92300 Levallois-Perret, France.
出版信息
Cancers (Basel). 2017 May 26;9(6):59. doi: 10.3390/cancers9060059.
Colorectal cancer is one of the most commonly diagnosed cancers worldwide and nearly half of patients will develop metastatic disease at some point during the course of their disease. The goal of anticancer therapy in this context is to extend survival, while trying to maximise the patient's health-related quality of life. To this end, we need to understand how to incorporate patient-reported outcomes into clinical trials and routine practice to accurately assess if treatment strategies are providing clinical benefit for the patient. This review reflects the proceedings of a 2016 European Society of Digestive Oncology workshop, where the authors discussed the use of patient-reported outcomes to measure health-related quality of life when evaluating treatment during the management of colorectal cancer. A summary of the challenges associated with implementing patient-reported outcomes in clinical trials is provided, as well as a review of the current clinical evidence surrounding patient-reported outcomes in metastatic colorectal cancer.
结直肠癌是全球最常被诊断出的癌症之一，近半数患者在病程的某个阶段会发生转移性疾病。在此背景下，抗癌治疗的目标是延长生存期，同时尽量提高患者与健康相关的生活质量。为此，我们需要了解如何将患者报告的结果纳入临床试验和常规实践，以准确评估治疗策略是否为患者带来临床益处。本综述反映了2016年欧洲消化肿瘤学会研讨会的会议记录，作者们在会上讨论了在评估结直肠癌治疗过程中使用患者报告的结果来衡量与健康相关的生活质量。文中提供了在临床试验中实施患者报告结果所面临挑战的总结，以及对转移性结直肠癌患者报告结果的当前临床证据的综述。
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