一种通过听觉刺激诱导人类皮质长时程增强的方法。
A method to induce human cortical long-term potentiation by acoustic stimulation.
作者信息
Lei Guanxiong, Zhao Zeqi, Li Yalan, Yu Liming, Zhang Xin, Yan Yan, Ma Xiaoyan, Wang Qian, Wang Keshuang, Zhang Duo, Shen Weidong, Qiao Yuehua, Yang Shiming
机构信息
a Department of Otorhinolaryngology, Head and Neck Surgery , Chinese PLA General Hospital , Beijing , China.
b Medical School, Nankai University , Tianjin , China.
出版信息
Acta Otolaryngol. 2017 Oct;137(10):1069-1076. doi: 10.1080/00016489.2017.1332428. Epub 2017 Jun 7.
OBJECT
Acoustic stimulation induced LTP in the human auditory cortex was successfully recorded for the first time by electroencephalography (EEG) using a stimulus of 1 kHz pure-tone in 2005. However, it was barely reproduced, given considerable challenges to reliably elicit and accurately record the enhanced potentials in vivo. The purpose of this paper was to explore whether acoustic stimuli other than 1 kHz pure-tone could generate LTP or not.
MEASURES
To answer this question, we proposed a tetanic-stimulation paradigm of pure-tones, narrow-band noises (NBNs) and white noise (WN) to elicit LTP in human subjects.
RESULTS
The results showed that pure-tones with different frequency could elicit LTP in human auditory cortex, and proved for the first time that NBNs and WN could also achieve the same goal. Interestingly, it was also shown that the noises with certain bandwidth induced the greatest LTP and the WN induced LTP had the least variation over time and across subjects in comparison with pure-tones and NBNs.
CONCLUSIONS
In light of the results, we suggested to use the paradigm for broader studies of human in vivo cortical plasticity.
目的
2005年，通过脑电图（EEG）首次成功记录了1kHz纯音刺激诱发的人类听觉皮层长时程增强（LTP）。然而，由于在体内可靠地引发和准确记录增强电位面临相当大的挑战，该结果几乎无法重现。本文的目的是探究除1kHz纯音之外的其他声刺激是否能产生LTP。
措施
为回答这个问题，我们提出了一种纯音、窄带噪声（NBN）和白噪声（WN）的强直刺激范式，以在人类受试者中诱发LTP。
结果
结果表明，不同频率的纯音可在人类听觉皮层诱发LTP，并首次证明NBN和WN也能达到相同目的。有趣的是，研究还表明，与纯音和NBN相比，具有特定带宽的噪声诱发的LTP最大，且WN诱发的LTP随时间和受试者的变化最小。
结论
鉴于这些结果，我们建议将该范式用于更广泛的人类体内皮层可塑性研究。
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