运动与心脏保护：致命性心肌缺血再灌注损伤的天然防御及心血管预防的潜在指导
Exercise and Cardioprotection: A Natural Defense Against Lethal Myocardial Ischemia-Reperfusion Injury and Potential Guide to Cardiovascular Prophylaxis.
机构信息
1 Department of Medicine, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
* Mohammed Andaleeb Chowdhury, Haden K. Sholl, and Megan S. Sharrett contributed equally to this work.
出版信息
J Cardiovasc Pharmacol Ther. 2019 Jan;24(1):18-30. doi: 10.1177/1074248418788575. Epub 2018 Jul 24.
Abstract
Similar to ischemic preconditioning, high-intensity exercise has been shown to decrease infarct size following myocardial infarction. In this article, we review the literature on beneficial effects of exercise, exercise requirements for cardioprotection, common methods utilized in laboratories to study this phenomenon, and discuss possible mechanisms for exercise-mediated cardioprotection.
摘要
与缺血预处理类似，高强度运动已被证明可减少心肌梗死后的梗死面积。在本文中，我们回顾了关于运动的有益作用、运动对心脏保护的要求、实验室研究这一现象常用的方法的文献，并讨论了运动介导的心脏保护的可能机制。
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本文引用的文献
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Modelling ischemia-reperfusion injury (IRI) using metabolically matured induced pluripotent stem cell-derived cardiomyocytes.使用代谢成熟的诱导多能干细胞衍生的心肌细胞模拟缺血再灌注损伤（IRI）。
APL Bioeng. 2018 Mar 20;2(2):026102. doi: 10.1063/1.5000746. eCollection 2018 Jun.
2
RCAN1-Calcineurin Axis and the Set-Point for Myocardial Damage During Ischemia-Reperfusion.RCAN1-钙调神经磷酸酶轴与缺血再灌注期间心肌损伤的设定点
Circ Res. 2018 Mar 16;122(6):796-798. doi: 10.1161/CIRCRESAHA.118.312787.
3
Exercise induces new cardiomyocyte generation in the adult mammalian heart.运动可在成年哺乳动物心脏中诱导产生新的心肌细胞。
Nat Commun. 2018 Apr 25;9(1):1659. doi: 10.1038/s41467-018-04083-1.
4
Human iPSC-Derived Cardiomyocytes for Investigation of Disease Mechanisms and Therapeutic Strategies in Inherited Arrhythmia Syndromes: Strengths and Limitations.人诱导多能干细胞衍生心肌细胞在遗传性心律失常综合征疾病机制和治疗策略研究中的应用：优势和局限性。
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5
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Basic Res Cardiol. 2017 Jul;112(4):38. doi: 10.1007/s00395-017-0628-z. Epub 2017 May 22.
6
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Cochrane Database Syst Rev. 2017 May 5;5(5):CD011719. doi: 10.1002/14651858.CD011719.pub3.
7
8
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9
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J Mol Cell Cardiol. 2017 Jan;102:26-30. doi: 10.1016/j.yjmcc.2016.11.008. Epub 2016 Nov 17.
10
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