确定的是，SIRT4的活性！

For Certain, SIRT4 Activities!

作者信息

Kumar Surinder, Lombard David B

机构信息

Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.

Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Institute of Gerontology, University of Michigan, Ann Arbor, MI 48109, USA.

出版信息

Trends Biochem Sci. 2017 Jul;42(7):499-501. doi: 10.1016/j.tibs.2017.05.008. Epub 2017 Jun 3.

DOI:10.1016/j.tibs.2017.05.008

PMID:28587732

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5518788/

Abstract

Despite the fact that SIRT4 regulates important biological processes, its primary enzymatic activity has remained ambiguous. A recent study by Anderson, Huynh et al. has uncovered deacylase activities of SIRT4 towards newly described lysine modifications derived from reactive acyl-CoAs generated in leucine catabolism.

摘要

尽管SIRT4调节重要的生物学过程，但其主要酶活性仍不明确。安德森、胡英等人最近的一项研究发现，SIRT4对亮氨酸分解代谢中产生的反应性酰基辅酶A衍生的新描述的赖氨酸修饰具有去酰基酶活性。