循环25-羟维生素D水平与肺癌患者的预后：一项系统评价和荟萃分析。

Circulating 25-hydroxyvitamin D level and prognosis of lung cancer patients: A systematic review and meta-analysis.

作者信息

Huang Jian-Da, Dong Chao-Hui, Shao Sheng-Wen, Gu Tong-Jie, Hu Zhi-Lin, Ying Jun, Zhou Dan-Fei, Xie Yan-Ping

机构信息

Ningbo N(o) 2 Hospital, Department of Respiratory Medicine, N(o) 41 Northwest Street, Ningbo, 315010 Zhejiang, China.

First Affiliated Hospital of Huzhou University, Department of Cardiology, N(o) 158 Guangchanghou Road, Huzhou, 313000 Zhejiang, China.

出版信息

Bull Cancer. 2017 Jul-Aug;104(7-8):675-682. doi: 10.1016/j.bulcan.2017.05.001. Epub 2017 Jun 3.

DOI:10.1016/j.bulcan.2017.05.001

PMID:28587766

Abstract

BACKGROUND

Previous studies suggested a possible influence of circulating 25-hydroxyvitamin D [25(OH)D] level on the prognosis of lung cancer patients, but conflicting findings were reported. A systematic review and meta-analysis was thus conducted to comprehensively assess the influence of circulating 25(OH)D level on the prognosis of lung cancer patients.

METHODS

Prospective or retrospective cohort studies assessing the influence of circulating 25(OH)D level on the prognosis of lung cancer patients were considered eligible. Hazard Ratios (HR) were pooled using meta-analysis.

RESULTS

Eight studies with 2166 lung cancer patients were included. Meta-analysis of unadjusted HRs from four studies showed low circulating 25(OH)D level was significantly correlated with poor overall survival in lung cancer (HR=1.30, 95%CI 1.08-1.55, P=0.004). Meta-analysis of adjusted HRs from eight studies suggested that low circulating 25(OH)D level was not significantly correlated with poor overall survival (HR=1.25; P=0.13). However, sensitivity analysis suggested an obvious change in the pooled HRs when excluding single study by turns. When the study by Liu et al. was omitted, low circulating 25(OH)D level was significantly correlated with poor overall survival (HR=1.34; P=0.04).

CONCLUSION

The present systematic review and meta-analysis suggested a correlation between low circulating 25(OH)D level and poor overall survival in lung cancer. More studies are needed to further validate the finding above.

摘要

背景

既往研究提示循环25-羟维生素D[25(OH)D]水平可能对肺癌患者的预后有影响，但报道结果相互矛盾。因此进行了一项系统评价和荟萃分析，以全面评估循环25(OH)D水平对肺癌患者预后的影响。

方法

评估循环25(OH)D水平对肺癌患者预后影响的前瞻性或回顾性队列研究被视为合格研究。采用荟萃分析汇总风险比(HR)。

结果

纳入8项研究，共2166例肺癌患者。对4项研究未调整的HR进行荟萃分析显示，循环25(OH)D水平低与肺癌患者总生存期差显著相关(HR=1.30，95%CI 1.08-1.55，P=0.004)。对8项研究调整后的HR进行荟萃分析提示，循环25(OH)D水平低与总生存期差无显著相关性(HR=1.25；P=0.13)。然而，敏感性分析提示依次排除单个研究时，汇总的HR有明显变化。当省略Liu等人的研究时，循环25(OH)D水平低与总生存期差显著相关(HR=1.34；P=0.04)。