Jones Terence A, Reddy Narendra L, Wayte Sarah C, Adesanya Oludolapo, Dimitriadis Georgios K, Hutchinson Charles E, Barber Thomas M
Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, Coventry, CV2 2DX, United Kingdom
Department of Radiology, University Hospitals Coventry and Warwickshire, Coventry, CV2 2DX, United Kingdom.
Physiol Rep. 2017 Jun;5(11). doi: 10.14814/phy2.13284.
Active brown adipose tissue (BAT) in humans has been demonstrated through use of positron emission tomography with 2-deoxy-2-(fluorine-18) fluoro-D-glucose integrated with computed tomography (F-FDG PET/CT) scans. The aim of our study was to determine whether active human BAT depots shown on F-FDG PET/CT scans remain static in their location over time. This was a retrospective study. Adult human subjects ( = 15) who had had F-FDG PET/CT imaging ( = 38 scans in total) for clinical reasons were included on the basis of F-FDG uptake patterns consistent with BAT activity. For each subject, F-FDG BAT uptake pattern on serial F-FDG PET/CT images was compared to an index F-FDG PET/CT image with the largest demonstrable BAT volume. Object-based colocalization was expressed as Mander's correlation coefficient (where 1 = 100% overlap, 0 = no overlap). Distribution of F-FDG BAT activity over time and across multiple F-FDG BAT scans was equivalent in 60% ( = 9) of the subjects. The degree of consistency in the pattern of F-FDG BAT uptake in each subject over time was greater than expected by chance in 87% ( = 13) of the subjects (pair-wise agreement 75-100%, Fleiss' 0.4-1). The degree of BAT colocalization on serial scans was greater than that expected by chance in 93% ( = 14) of the subjects (mean Mander's coefficient 0.81 ± 0.21 [95% CI]). To our knowledge, our study provides the most conclusive evidence to date to support the notion that active BAT depots in humans (volumes and activities of which were measured through use of F-FDG PET/CT scans) remain static in location over sustained periods.
通过使用正电子发射断层扫描与计算机断层扫描（F-FDG PET/CT）相结合的2-脱氧-2-（氟-18）氟-D-葡萄糖，已证实人体中存在活跃的棕色脂肪组织（BAT）。我们研究的目的是确定F-FDG PET/CT扫描显示的活跃人体BAT库在一段时间内其位置是否保持不变。这是一项回顾性研究。基于与BAT活动一致的F-FDG摄取模式，纳入了因临床原因进行过F-FDG PET/CT成像（总共38次扫描）的成年人类受试者（n = 15）。对于每个受试者，将系列F-FDG PET/CT图像上的F-FDG BAT摄取模式与具有最大可显示BAT体积的索引F-FDG PET/CT图像进行比较。基于对象的共定位用曼德相关系数表示（其中1 = 100%重叠，0 = 无重叠）。60%（n = 9）的受试者中，F-FDG BAT活性随时间和多次F-FDG BAT扫描的分布是等效的。87%（n = 13）的受试者中，每个受试者F-FDG BAT摄取模式随时间的一致程度大于随机预期（两两一致性75 - 100%，Fleiss'κ 0.4 - 1）。93%（n = 14）的受试者中，系列扫描中BAT共定位程度大于随机预期（平均曼德系数0.81±0.21 [95% CI]）。据我们所知，我们的研究提供了迄今为止最确凿的证据，支持以下观点：人体中的活跃BAT库（其体积和活性通过F-FDG PET/CT扫描测量）在较长时间内位置保持不变。
