Alenezi Saud A, Dannoon Shorouk F, Alnafisi Naheel S, Asa'ad Saqr M, Osman Medhat M, Elgazzar Abdelhamid H
Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, Safat, Kuwait.
Department of Nuclear Medicine, Farwaniya Hospital, Sabah Al Nasser, Kuwait.
World J Nucl Med. 2020 Jan 14;19(1):41-46. doi: 10.4103/wjnm.WJNM_16_19. eCollection 2020 Jan-Mar.
The aim of this study is to investigate the relationship between brown adipose tissue (BAT) activation and myocardial fluorine-18-fluorodeoxyglucose ([F] FDG) uptake in terms of intensity and patterns. The patients were divided into two groups as follows: BAT and control groups. The BAT group consists of 34 cases that showed BAT uptake. The control group, with no BAT uptake, included 68 patients who were matched for body mass index, gender, and season. The scans were retrospectively reviewed by two nuclear medicine physicians who visually evaluated the intensity of myocardial [F] FDG uptake. The myocardial [F] FDG uptake was visually classified into the following three patterns: diffuse, heterogeneous, and focal. The regions of activated BAT distribution were noted. The mean myocardial [F] FDG uptake was 2.50 ± 0.75 for the BAT group and 2.13 ± 0.88 for the control group with a statistically significant difference ( = 0.031). The myocardial [F] FDG uptake pattern was similar in the BAT and control groups with the diffuse pattern being the most common, followed by the heterogeneous and less commonly focal. In the BAT group, the anatomical distribution of BAT was mainly in supraclavicular, paravertebral, and axillary and to a lesser extent in cervical regions. BAT group had a significantly higher intensity of [F] FDG myocardial uptake compared to that of the control group. The presence of activated BAT did not affect the pattern of myocardial uptake. Knowledge of these findings may help in understanding the variability of myocardial [F] FDG uptake and consequently in avoiding misinterpretation of cardiac findings in positron-emission tomography/computed tomography studies.
本研究的目的是从强度和模式方面探讨棕色脂肪组织（BAT）激活与心肌氟-18-氟脱氧葡萄糖（[F]FDG）摄取之间的关系。患者分为以下两组：BAT组和对照组。BAT组由34例显示BAT摄取的病例组成。对照组无BAT摄取，包括68例在体重指数、性别和季节方面匹配的患者。两名核医学医生对扫描结果进行了回顾性评估，他们通过视觉评估心肌[F]FDG摄取的强度。心肌[F]FDG摄取在视觉上分为以下三种模式：弥漫性、不均匀性和局灶性。记录激活的BAT分布区域。BAT组心肌[F]FDG摄取的平均值为2.50±0.75，对照组为2.13±0.88，差异有统计学意义（=0.031）。BAT组和对照组的心肌[F]FDG摄取模式相似，弥漫性模式最为常见，其次是不均匀性模式，局灶性模式较少见。在BAT组中，BAT的解剖分布主要在锁骨上、椎旁和腋窝，在颈部区域较少。与对照组相比，BAT组心肌[F]FDG摄取强度明显更高。激活的BAT的存在并不影响心肌摄取模式。了解这些发现可能有助于理解心肌[F]FDG摄取的变异性，从而有助于避免在正电子发射断层扫描/计算机断层扫描研究中对心脏检查结果的错误解读。
