Department of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, 55 Fruit St, White 270, Boston, MA 02114, USA.
Radiology. 2012 Jun;263(3):836-42. doi: 10.1148/radiol.12100683.
To assess the prevalence of brown fat in patients with cancer, compare demographic characteristics of those with and those without brown fat, and correlate these characteristics with the mean and maximum standardized uptake values of brown fat.
This case-control study was institutional review board approved and HIPAA compliant. Informed consent was waived. Reports of 12 195 consecutive positron emission tomography/computed tomography examinations performed in 6867 patients between January 2004 and November 2008 were reviewed for documented fluorodeoxyglucose (FDG) uptake in brown fat (n = 298). Control patients (n = 298) without brown fat were chosen and matched for age, sex, and month and year of examination. Age, sex, weight, body mass index, ethnicity, and examination stage (initial vs restaging) were compared between groups. Paired Student t test, χ(2) test, Pearson correlation coefficient, and analysis of variance were used for statistical analysis.
Uptake of FDG in brown fat was demonstrated in 298 of 6867 (4.33%) patients. Prevalence of brown fat was significantly higher in female (5.9% [211 of 3587]) than in male patients (2.65% [87 of 3280]; P < .001). Those with brown fat had significantly lower body weight (147.5 lb ± 3.8 vs 168.61 lb ± 5.0; P < .001) and body mass index (24.3 ± 0.54 vs 27.6 ± 0.77; P < .001) than control patients. There was no significant difference in the prevalence of brown fat among ethnic groups. The maximum standardized uptake value of brown fat had a significant inverse correlation with age (r = -0.3, P < .001).
Patients with brown fat were more likely to be female and thinner than those without brown fat. Younger patients were more likely to have higher maximum standardized uptake values of brown fat.
评估癌症患者中棕色脂肪的发生率，比较有和无棕色脂肪的患者的人口统计学特征，并将这些特征与棕色脂肪的平均和最大标准化摄取值相关联。
本病例对照研究获得机构审查委员会批准，并符合 HIPAA 规定。已豁免知情同意。对 2004 年 1 月至 2008 年 11 月期间在 6867 例患者中进行的 12195 例连续正电子发射断层扫描/计算机断层扫描检查报告进行了回顾，以评估棕色脂肪（n = 298）中记录的氟脱氧葡萄糖（FDG）摄取情况。选择了无棕色脂肪的对照患者（n = 298），并按年龄、性别以及检查月份和年份进行匹配。比较两组患者的年龄、性别、体重、体重指数、种族和检查阶段（初始检查与再分期检查）。使用配对学生 t 检验、卡方检验、皮尔逊相关系数和方差分析进行统计学分析。
在 6867 例患者中，有 298 例（4.33%）患者显示 FDG 在棕色脂肪中有摄取。女性（5.9%[211/3587]）棕色脂肪的发生率明显高于男性（2.65%[87/3280]；P<.001）。有棕色脂肪的患者体重明显较轻（147.5 磅±3.8 与 168.61 磅±5.0；P<.001），体重指数也较低（24.3±0.54 与 27.6±0.77；P<.001）。不同种族之间棕色脂肪的发生率无显著差异。棕色脂肪的最大标准化摄取值与年龄呈显著负相关（r = -0.3，P<.001）。
有棕色脂肪的患者比无棕色脂肪的患者更可能是女性且更瘦。年轻患者更可能有较高的棕色脂肪最大标准化摄取值。
