Hadfield James, Harris Simon R, Seth-Smith Helena M B, Parmar Surendra, Andersson Patiyan, Giffard Philip M, Schachter Julius, Moncada Jeanne, Ellison Louise, Vaulet María Lucía Gallo, Fermepin Marcelo Rodríguez, Radebe Frans, Mendoza Suyapa, Ouburg Sander, Morré Servaas A, Sachse Konrad, Puolakkainen Mirja, Korhonen Suvi J, Sonnex Chris, Wiggins Rebecca, Jalal Hamid, Brunelli Tamara, Casprini Patrizia, Pitt Rachel, Ison Cathy, Savicheva Alevtina, Shipitsyna Elena, Hadad Ronza, Kari Laszlo, Burton Matthew J, Mabey David, Solomon Anthony W, Lewis David, Marsh Peter, Unemo Magnus, Clarke Ian N, Parkhill Julian, Thomson Nicholas R
Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom.
Public Health England, Public Health Laboratory Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QW, United Kingdom.
Genome Res. 2017 Jul;27(7):1220-1229. doi: 10.1101/gr.212647.116. Epub 2017 Jun 6.
is the world's most prevalent bacterial sexually transmitted infection and leading infectious cause of blindness, yet it is one of the least understood human pathogens, in part due to the difficulties of in vitro culturing and the lack of available tools for genetic manipulation. Genome sequencing has reinvigorated this field, shedding light on the contemporary history of this pathogen. Here, we analyze 563 full genomes, 455 of which are novel, to show that the history of the species comprises two phases, and conclude that the currently circulating lineages are the result of evolution in different genomic ecotypes. Temporal analysis indicates these lineages have recently expanded in the space of thousands of years, rather than the millions of years as previously thought, a finding that dramatically changes our understanding of this pathogen's history. Finally, at a time when almost every pathogen is becoming increasingly resistant to antimicrobials, we show that there is no evidence of circulating genomic resistance in .
是世界上最普遍的细菌性性传播感染，也是导致失明的主要感染原因，但它却是人们了解最少的人类病原体之一，部分原因是体外培养困难以及缺乏可用的基因操作工具。基因组测序为该领域注入了新活力，揭示了这种病原体的当代历史。在这里，我们分析了563个全基因组，其中455个是新的，以表明该物种的历史包括两个阶段，并得出结论，目前正在传播的谱系是不同基因组生态型进化的结果。时间分析表明，这些谱系最近在数千年的时间里扩张，而不是像以前认为的数百万年，这一发现极大地改变了我们对这种病原体历史的理解。最后，在几乎每种病原体对抗微生物药物的耐药性都日益增强的时代，我们表明没有证据表明 中存在循环基因组耐药性。
