Tseng Kuo-Chih, Lin Ming-Nan, Chu Tang-Yuan, Tsai Jen-Pi, Su Cheng-Chuan
School of Medicine, Tzu Chi University, Hualien 970, Taiwan.
Department of Internal Medicine, Buddhist Dalin Tzu Chi Hospital, Chiayi County 622, Taiwan.
Emerg Microbes Infect. 2017 Jun 7;6(6):e45. doi: 10.1038/emi.2017.32.
The high seroprevalence of human herpesvirus type 8 (HHV-8) in moderate or severe cirrhotics appears to be associated with male sex, hepatitis B virus (HBV) infection, alcoholism, and disease severity. The status of HHV-8 infection in mild cirrhotics remains unclear. Plasma samples collected from 93 mild cirrhotics and 93 age- and sex-matched healthy controls were analyzed for HHV-8 antibody and HHV-8 DNA. Mild cirrhotics had higher seropositivity for HHV-8 antibodies than healthy controls (P=0.0001). Univariate logistic regression analysis revealed that an age ≥55 years (odds ratio (OR) 2.88, P=0.02), hepatitis C virus (HCV) infection (OR 3.42, P=0.01), and hepatitis activity (OR 4.10, P=0.004) were associated with HHV-8 seropositivity in cirrhotics. Stepwise multivariate logistic regression analysis confirmed that age ≥55 years (adjusted OR (aOR) 1.92, P=0.04) and hepatitis activity (aOR 3.55, P=0.005) were independent factors. The rate of hepatitis activity was higher in HCV-infected than in HBV-infected patients (P<0.0001) and in women than in men (P=0.0001). Cirrhotics who were seropositive for HHV-8 or HCV or had hepatitis activity were significantly older (P=0.02, <0.0001 and <0.0001, respectively). Plasma samples from all participants were negative for HHV-8 DNA. HHV-8 antibody titers in mild cirrhotics also markedly exceeded those in controls (P<0.0001), as did those in patients ≥55 years old vs. younger patients (P=0.01), those in patients with vs. without HCV infection (P=0.0008), and those in patients with vs. without hepatitis activity (P=0.0005). Mild cirrhotics had high HHV-8 seroprevalence and HCV infection, and, in particular, old age and hepatitis activity were predictors.
在中度或重度肝硬化患者中，人类疱疹病毒8型（HHV-8）的高血清阳性率似乎与男性、乙型肝炎病毒（HBV）感染、酗酒及疾病严重程度有关。轻度肝硬化患者中HHV-8感染状况尚不清楚。对93例轻度肝硬化患者及93例年龄和性别匹配的健康对照者采集的血浆样本进行HHV-8抗体及HHV-8 DNA分析。轻度肝硬化患者的HHV-8抗体血清阳性率高于健康对照者（P=0.0001）。单因素逻辑回归分析显示，年龄≥55岁（比值比（OR）2.88，P=0.02）、丙型肝炎病毒（HCV）感染（OR 3.42，P=0.01）及肝炎活动度（OR 4.10，P=0.004）与肝硬化患者的HHV-8血清阳性有关。逐步多因素逻辑回归分析证实，年龄≥55岁（校正OR（aOR）1.92，P=0.04）及肝炎活动度（aOR 3.55，P=0.005）为独立因素。HCV感染患者的肝炎活动度发生率高于HBV感染患者（P<0.0001），女性高于男性（P=0.0001）。HHV-8、HCV血清阳性或有肝炎活动度的肝硬化患者年龄显著更大（分别为P=0.02、<0.0001及<0.0001）。所有参与者的血浆样本HHV-8 DNA均为阴性。轻度肝硬化患者的HHV-8抗体滴度也显著高于对照者（P<0.0001），≥55岁患者与年轻患者相比（P=0.01）、有HCV感染与无HCV感染患者相比（P=0.0008）、有肝炎活动度与无肝炎活动度患者相比（P=0.0005）亦是如此。轻度肝硬化患者HHV-8血清阳性率及HCV感染率高，尤其是高龄及肝炎活动度为预测因素。
