影响干细胞迁移的环境因素：“电场”。
Environmental Factors That Influence Stem Cell Migration: An "Electric Field".
作者信息
Iwasa Stephanie N, Babona-Pilipos Robart, Morshead Cindi M
机构信息
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada M5S 3E1.
Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada M4G 3V9.
出版信息
Stem Cells Int. 2017;2017:4276927. doi: 10.1155/2017/4276927. Epub 2017 May 15.
Abstract
The movement of cells in response to electric potential gradients is called galvanotaxis. In vivo galvanotaxis, powered by endogenous electric fields (EFs), plays a critical role during development and wound healing. This review aims to provide a perspective on how stem cells transduce EFs into directed migration and an understanding of the current literature relating to the mechanisms by which cells sense and transduce EFs. We will comment on potential EF-based regenerative medicine therapeutics.
摘要
细胞响应电势梯度的运动被称为趋电运动。由内源性电场（EFs）驱动的体内趋电运动在发育和伤口愈合过程中起着关键作用。本综述旨在阐述干细胞如何将电场转化为定向迁移，并解读当前有关细胞感知和转化电场机制的文献。我们将对基于电场的潜在再生医学疗法进行评论。
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