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针刺对COH大鼠围植入期子宫内膜血管生成及子宫树突状细胞的影响

Effect of Acupuncture on Endometrial Angiogenesis and Uterus Dendritic Cells in COH Rats during Peri-Implantation Period.

作者信息

Dong Haoxu, Zhong Zhiyan, Chen Wei, Wu Xiao, Zhang Qing, Huang Guangying, Yang Wei

机构信息

Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei 430030, China.

Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei 430030, China.

出版信息

Evid Based Complement Alternat Med. 2017;2017:3647080. doi: 10.1155/2017/3647080. Epub 2017 May 14.

DOI:10.1155/2017/3647080
PMID:28588637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5446881/
Abstract

This study was to explore the mechanism of acupuncture on regulating the endometrial angiogenesis and uterus dendritic cells (uDCs) during the peri-implantation period. Rats, in early pregnancy, were randomized into five groups: normal (N), model (M), acupuncture (A), progesterone (P), and A + P groups. The COH model was established using pregnant mare serum, combined with human chorionic gonadotrophin. Endometrium was collected on days 4, 6, and 8 (D4, D6, and D8) of gestation. Compared with group M, both VEGF and FGF-2 protein and mRNA levels were significantly lower on D4 and higher on D6 and D8 ( < 0.05), except for VEGF of group P on D8; the proportion of uterus dendritic cells (uDCs) in the endometrium was significantly lower on D4 and D6 and higher on D8 ( < 0.05). In vitro, except for the proliferation of group P on D8, proliferation, tube formation, and migration of uDCs were significantly decreased on D4 and increased on D8 ( < 0.05). In addition, acupuncture or progesterone regulated the secretion levels of VEGF, IL-15, and IL-18 secreted by uDCs instead of soluble sFLT-1. In conclusion, acupuncture may regulate angiogenesis of the endometrium and the number and roles of uDCs after COH, and the specific mechanism may be different with progesterone.

摘要

本研究旨在探讨针刺在着床期调节子宫内膜血管生成及子宫树突状细胞（uDCs）的机制。将妊娠早期大鼠随机分为五组：正常组（N）、模型组（M）、针刺组（A）、孕酮组（P）和针刺+孕酮组（A+P）。采用孕马血清联合人绒毛膜促性腺激素建立控制性超促排卵（COH）模型。在妊娠第4、6、8天（D4、D6和D8）采集子宫内膜。与M组相比，除P组D8天的VEGF外，D4天VEGF和FGF-2蛋白及mRNA水平均显著降低，D6和D8天则升高（<0.05）；子宫内膜中子宫树突状细胞（uDCs）的比例在D4和D6天显著降低，D8天升高（<0.

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