Cell and Molecular Biology Graduate Program and.
Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan, USA.
JCI Insight. 2023 Jun 8;8(11):e163422. doi: 10.1172/jci.insight.163422.
Uterine vascular remodeling is intrinsic to the cycling and early pregnant endometrium. Maternal regulatory factors such as ovarian hormones, VEGF, angiopoietins, Notch, and uterine natural killer cells significantly mediate these vascular changes. In the absence of pregnancy, changes in uterine vessel morphology and function correlate with different stages of the human menstrual cycle. During early pregnancy, vascular remodeling in rodents and humans results in decreased uterine vascular resistance and increased vascular permeability necessary for pregnancy success. Aberrations in these adaptive vascular processes contribute to increased risk of infertility, abnormal fetal growth, and/or preeclampsia. This Review comprehensively summarizes uterine vascular remodeling in the human menstrual cycle, and in the peri- and post-implantation stages in rodent species (mice and rats).
子宫血管重塑是月经周期和早期妊娠子宫内膜的固有特性。母体调节因子，如卵巢激素、VEGF、血管生成素、Notch 和子宫自然杀伤细胞，显著介导这些血管变化。在没有妊娠的情况下，子宫血管形态和功能的变化与人类月经周期的不同阶段相关。在早期妊娠中，啮齿动物和人类的血管重塑导致子宫血管阻力降低和血管通透性增加，这对于妊娠成功是必要的。这些适应性血管过程的异常导致不孕、胎儿生长异常和/或子痫前期的风险增加。本综述全面总结了人类月经周期以及啮齿动物（小鼠和大鼠）的种植前和种植后阶段的子宫血管重塑。
