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阴道尤因肉瘤:儿科患者中一种罕见的临床实体。

Vaginal Ewing Sarcoma: An Uncommon Clinical Entity in Pediatric Patients.

作者信息

Cross Nathan M, Stanescu A Luana, Rudzinski Erin R, Hawkins Douglas S, Parisi Marguerite T

机构信息

Department of Radiology, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.

Department of Pathology, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.

出版信息

J Clin Imaging Sci. 2017 Apr 25;7:17. doi: 10.4103/jcis.JCIS_96_16. eCollection 2017.

DOI:10.4103/jcis.JCIS_96_16
PMID:28589056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5433652/
Abstract

Ewing sarcoma, including classical Ewing sarcoma of the bone and primitive neuroectodermal tumors arising in bone or extraosseous primary sites, is a highly aggressive childhood neoplasm. We present two cases of Ewing sarcoma arising from the vagina in young girls. Previously reported cases in literature focused on their pathologic rather than radiographic features. We describe the spectrum of multimodality imaging appearances of Ewing sarcoma at this unusual primary site. Awareness of vaginal Ewing tumors may facilitate prompt diagnosis and lead to a different surgical approach than the more commonly encountered vaginal rhabdomyosarcoma.

摘要

尤因肉瘤,包括骨的经典尤因肉瘤以及发生于骨或骨外原发部位的原始神经外胚层肿瘤,是一种侵袭性很强的儿童肿瘤。我们报告两例发生于年轻女孩阴道的尤因肉瘤。文献中先前报道的病例侧重于其病理特征而非影像学特征。我们描述了尤因肉瘤在这个不寻常的原发部位的多模态影像学表现。认识阴道尤因肿瘤可能有助于早期诊断,并导致与更常见的阴道横纹肌肉瘤不同的手术方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dba/5433652/6e96eb4de9ff/JCIS-7-17-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dba/5433652/0999ceafc3fe/JCIS-7-17-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dba/5433652/6e96eb4de9ff/JCIS-7-17-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dba/5433652/0999ceafc3fe/JCIS-7-17-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dba/5433652/6e96eb4de9ff/JCIS-7-17-g003.jpg

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本文引用的文献

1
Time to diagnosis of Ewing tumors in children and adolescents is not associated with metastasis or survival: a prospective multicenter study of 436 patients.儿童和青少年尤文氏瘤的诊断时间与转移或生存无关:436 例患者的前瞻性多中心研究。
J Clin Oncol. 2014 Jun 20;32(18):1935-40. doi: 10.1200/JCO.2013.53.8058. Epub 2014 May 19.
2
Multimodality imaging features, metastatic pattern and clinical outcome in adult extraskeletal Ewing sarcoma: experience in 26 patients.成人骨外尤文肉瘤的多模态影像学特征、转移模式和临床转归:26 例患者的经验。
Br J Radiol. 2014 Jun;87(1038):20140123. doi: 10.1259/bjr.20140123. Epub 2014 Apr 15.
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原发性阴道尤文肉瘤合并子宫肌瘤:一例报告。
Medicine (Baltimore). 2020 Jul 2;99(27):e20859. doi: 10.1097/MD.0000000000020859.
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Role of surgery in gynaecological sarcomas.手术在妇科肉瘤中的作用。
Oncotarget. 2019 Apr 2;10(26):2561-2575. doi: 10.18632/oncotarget.26803.
Appearance of extraosseous pelvic Ewing sarcoma on triphasic bone scan.
骨三相扫描中骨盆外尤文肉瘤的表现。
Clin Nucl Med. 2014 Apr;39(4):406-8. doi: 10.1097/RLU.0000000000000381.
4
From the radiologic pathology archives: ewing sarcoma family of tumors: radiologic-pathologic correlation.从放射病理学档案中:尤文肉瘤家族肿瘤:放射病理学相关性。
Radiographics. 2013 May;33(3):803-31. doi: 10.1148/rg.333135005.
5
Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group.随机对照试验研究间隔压缩化疗治疗局限性尤因肉瘤:儿童肿瘤协作组的报告。
J Clin Oncol. 2012 Nov 20;30(33):4148-54. doi: 10.1200/JCO.2011.41.5703. Epub 2012 Oct 22.
6
Preliminary efficacy of the anti-insulin-like growth factor type 1 receptor antibody figitumumab in patients with refractory Ewing sarcoma.抗胰岛素样生长因子 1 型受体抗体 figitumumab 治疗难治性尤文肉瘤患者的初步疗效。
J Clin Oncol. 2011 Dec 1;29(34):4534-40. doi: 10.1200/JCO.2010.33.0670. Epub 2011 Oct 24.
7
Primary vaginal Ewing sarcoma: case report and review of the literature.原发性阴道尤因肉瘤:病例报告及文献复习
Int J Surg Pathol. 2012 Jun;20(3):305-10. doi: 10.1177/1066896911424898. Epub 2011 Oct 17.
8
Clinical features and outcomes in patients with extraskeletal Ewing sarcoma.骨外尤文肉瘤患者的临床特征和转归。
Cancer. 2011 Jul 1;117(13):3027-32. doi: 10.1002/cncr.25840. Epub 2011 Jan 10.
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J Med Case Rep. 2010 Mar 17;4:88. doi: 10.1186/1752-1947-4-88.
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Primary vaginal extraosseous Ewing sarcoma/primitive neuroectodermal tumor with cranial metastasis.原发性阴道骨外尤文肉瘤/原始神经外胚层肿瘤伴颅骨转移。
J Chin Med Assoc. 2009 Jun;72(6):332-5. doi: 10.1016/S1726-4901(09)70381-8.