State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P.R. China.
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou, 730000, P.R. China.
J Org Chem. 2017 Jul 7;82(13):7000-7007. doi: 10.1021/acs.joc.7b00879. Epub 2017 Jun 21.
Copper-catalyzed [2 + 2 + 3] annulation of 1,6-enynes with α-bromo-1,3-dicarbonyl compounds is described. This reaction provides facile access to seven-membered dihydrooxepines for epidithiodiketopiperazines with two newly formed C-C bonds and one C-O bond.
铜催化的 1,6-烯炔与α-溴代 1,3-二羰基化合物的[2 + 2 + 3]环加成反应得到了描述。该反应为具有两个新形成的 C-C 键和一个 C-O 键的二氢恶唑啉提供了简便的方法来获得表二硫代二酮哌嗪。
