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基于全固相肽合成的方法合成明胶酶生物合成激活肽（GBAP）类似物文库：研究粪肠球菌群体感应信号的构效关系。

An Entirely Solid Phase Peptide Synthesis-Based Strategy for Synthesis of Gelatinase Biosynthesis-Activating Pheromone (GBAP) Analogue Libraries: Investigating the Structure-Activity Relationships of the Enterococcus faecalis Quorum Sensing Signal.

机构信息

Department of Chemistry, University of Nevada, Reno , 1664 North Virginia Street, Reno, Nevada 89557, United States.

出版信息

Org Lett. 2017 Jun 16;19(12):3295-3298. doi: 10.1021/acs.orglett.7b01444. Epub 2017 Jun 7.

DOI:10.1021/acs.orglett.7b01444
PMID:28590764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5551036/
Abstract

The development of an entirely solid-phase peptide synthesis (SPPS)-based synthesis of the quorum sensing signal gelatinase biosynthesis-activating pheromone (GBAP) from Enterococcus faecalis is reported. The method was used to prepare three libraries of analogues to investigate the structure-activity relationships (SARs) of the GBAP signal. The SAR studies revealed new characteristics of the GBAP signal and uncovered the most potent quorum sensing activator in E. faecalis known to date.

摘要

本文报道了一种基于全固相肽合成（SPPS）的粪肠球菌群体感应信号明胶酶生物合成激活肽（GBAP）合成方法。该方法用于制备三种类似物文库，以研究 GBAP 信号的结构-活性关系（SAR）。SAR 研究揭示了 GBAP 信号的新特征，并发现了迄今为止在粪肠球菌中已知的最有效的群体感应激活剂。

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2
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Trends Pharmacol Sci. 2017 Apr;38(4):339-362. doi: 10.1016/j.tips.2017.01.004. Epub 2017 Feb 14.
3
Quorum sensing signal-response systems in Gram-negative bacteria.革兰氏阴性菌中的群体感应信号应答系统。
Nat Rev Microbiol. 2016 Aug 11;14(9):576-88. doi: 10.1038/nrmicro.2016.89.
4
Advances in Fmoc solid-phase peptide synthesis.芴甲氧羰基固相肽合成的进展。
J Pept Sci. 2016 Jan;22(1):4-27. doi: 10.1002/psc.2836.
5
Competition studies confirm two major barriers that can preclude the spread of resistance to quorum-sensing inhibitors in bacteria.竞争研究证实了两个主要障碍，这两个障碍可能会阻止细菌对群体感应抑制剂的耐药性传播。
ACS Chem Biol. 2014 Oct 17;9(10):2291-9. doi: 10.1021/cb5004288. Epub 2014 Aug 19.
6
Quorum quenching agents: resources for antivirulence therapy.群体感应淬灭剂：抗毒力治疗的资源
Mar Drugs. 2014 May 30;12(6):3245-82. doi: 10.3390/md12063245.
7
Peptide pheromone signaling in Streptococcus and Enterococcus.链球菌和肠球菌中的肽信息素信号传导。
FEMS Microbiol Rev. 2014 May;38(3):473-92. doi: 10.1111/1574-6976.12046. Epub 2013 Oct 31.
8
Quorum quenching enzymes and their application in degrading signal molecules to block quorum sensing-dependent infection.群体感应淬灭酶及其在降解信号分子以阻断群体感应依赖性感染中的应用。
Int J Mol Sci. 2013 Aug 26;14(9):17477-500. doi: 10.3390/ijms140917477.
9
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Cold Spring Harb Perspect Med. 2012 Nov 1;2(11):a012427. doi: 10.1101/cshperspect.a012427.