a Faculty of Medicine and Life Sciences , University of Tampere , Tampere , Finland.
b Department of Obstetrics and Gynecology , Tampere University Hospital , Tampere , Finland.
Ann Med. 2017 Dec;49(8):636-643. doi: 10.1080/07853890.2017.1339907. Epub 2017 Jun 23.
Although metabolic syndrome (MetS) is evidently associated with the risk of cardiovascular disease (CVD), recently its use has been questioned. We studied the utility of MetS diagnosis when estimating individual CVD risk.
We compared 27 fertile women with MetS and 27 counterparts without the syndrome, matched pairwise according to well-known risk factors of CVD. Pulse wave velocity (PWV) and central blood pressure (cBP) were determined noninvasively via a SphygmoCor device. Arterial compliance was measured noninvasively with an HDI/PulseWaveCR-2000 arterial tonometer.
PWV (7.1 ± 2.5 versus 6.5 ± 1.1 m/s, p = .037), and both systolic (120.9 ± 12.2 versus 111.5 ± 16.0 mmHg, p = .031) and diastolic cBP (81.3 ± 8.5 versus 74.1 ± 11.2 mmHg, p = .035) were higher in the MetS group. Systemic arterial compliance values were lower in both large (15.1 ± 8.0 versus 16.1 ± 4.4 mL/mmHg × 10, p = .034) and small arteries (7.1 ± 2.5 versus 9.3 ± 3.2 mL/mmHg ×100, p = .010) in women with MetS.
Fertile women with MetS had increased arterial stiffness, as measured by three different methods. Our results highlight the utility of MetS when revealing increased individual CVD risks in fertile-aged women. Key messages Women with MetS have increased arterial stiffness when measured by different methods. MetS is a useful clinical tool to assess increased cardiovascular risk, particularly among fertile-aged women.
尽管代谢综合征（MetS）与心血管疾病（CVD）的风险明显相关，但最近其应用受到了质疑。我们研究了 MetS 诊断在估计个体 CVD 风险中的效用。
我们比较了 27 名患有 MetS 的生育期妇女和 27 名无代谢综合征的对照者，根据 CVD 的已知危险因素进行配对匹配。通过 SphygmoCor 设备无创性地确定脉搏波速度（PWV）和中心血压（cBP）。使用 HDI/PulseWaveCR-2000 动脉张力计无创性地测量动脉顺应性。
PWV（7.1±2.5 与 6.5±1.1 m/s，p=0.037），以及收缩压（120.9±12.2 与 111.5±16.0mmHg，p=0.031）和舒张压 cBP（81.3±8.5 与 74.1±11.2mmHg，p=0.035）在 MetS 组中更高。大动脉（15.1±8.0 与 16.1±4.4mL/mmHg×10，p=0.034）和小动脉（7.1±2.5 与 9.3±3.2mL/mmHg×100，p=0.010）的系统动脉顺应性值在患有 MetS 的妇女中均较低。
患有 MetS 的生育期妇女的动脉僵硬度增加，通过三种不同的方法测量。我们的结果强调了 MetS 在揭示生育年龄妇女增加的个体 CVD 风险中的有用性。
患有 MetS 的妇女的动脉僵硬度通过不同的方法测量时会增加。MetS 是评估心血管风险增加的有用临床工具，特别是在生育年龄的妇女中。
