Petersson B, Kristenson H, Trell E, Hood B
Ciba Found Symp. 1985;110:143-63. doi: 10.1002/9780470720912.ch10.
In the Malmö Preventive Programme the tracing and prevention of alcohol-related disease was attempted by means of the enzyme serum gamma-glutamyltransferase (GGT) in a large unselected population of middle-aged men. Alcohol was considered to be the underlying factor in 70% of subjects with raised GGT values. In a prospective analysis, alcohol-related death turned out to be a major contributor to death in men who died within five years of the screening. GGT was the variable that was most predictive for premature death in this population. There were also statistically significant correlations between alcohol-related death and a questionnaire, the Mm-MAST, positively, and serum creatinine and serum cholesterol, negatively. In the randomized intervention programme, reductions in sickness benefit days, hospital admissions and mortality were seen in the intervention group in comparison with the control group, after four years of follow-up. The intervention programme was therefore effective in preventing the consequences of heavy drinking, and a risk factor approach to alcohol-related diseases seems feasible. This approach, however, encounters several problems, such as the recruitment of the non-participants in the screening, the investigation of the GGT-high/non-alcoholic subjects, and the identification of the GGT-normal/alcoholic subjects.
在马尔默预防项目中，通过检测血清γ-谷氨酰转移酶（GGT），在一大群未经挑选的中年男性中尝试追踪和预防与酒精相关的疾病。在GGT值升高的受试者中，70%的人被认为酒精是潜在因素。在一项前瞻性分析中，与酒精相关的死亡被证明是筛查后五年内死亡男性死亡的主要原因。GGT是该人群中对过早死亡最具预测性的变量。与酒精相关的死亡与Mm-MAST问卷呈正相关，与血清肌酐和血清胆固醇呈负相关，这些相关性也具有统计学意义。在随机干预项目中，经过四年的随访，与对照组相比，干预组的疾病津贴天数、住院次数和死亡率均有所降低。因此，干预项目在预防酗酒后果方面是有效的，对与酒精相关疾病采取风险因素方法似乎是可行的。然而，这种方法遇到了几个问题，例如筛查中未参与者的招募、GGT值高/非酒精性受试者的调查以及GGT值正常/酒精性受试者的识别。
