Kristenson H
Recent Dev Alcohol. 1987;5:403-23. doi: 10.1007/978-1-4899-1684-6_17.
More than 30,000 individuals have been investigated in the continuous screening and intervention study in Malmö. Large subsamples of individuals with different levels of serum gamma-glutamyltransferase (GGT) have been characterized and followed up; GGT has proved to be a useful and simple tool in identifying and treating heavy drinkers and monitoring their outcome. In the intervention study, counseling and repeated feedback of GGT results in a group of middle-aged heavy drinkers led to a significant reduction in sick absence, hospitalization, and mortality compared with those in a control group over a period of 6 to 8 years. At follow-up, about 15% of middle-aged men in the general population had serious alcohol problems. Assessment and treatment of heavy drinkers within general medicine would provide a very considerable impact on the total problem of alcohol-related disease.
在马尔默进行的持续筛查和干预研究中，已有3万多人接受了调查。对不同血清γ-谷氨酰转移酶（GGT）水平的个体进行了大量子样本分析并跟踪随访；GGT已被证明是识别和治疗酗酒者以及监测其治疗效果的一种有用且简便的工具。在干预研究中，对一组中年酗酒者进行咨询并反复反馈GGT结果，与对照组相比，在6至8年的时间里，病假、住院率和死亡率显著降低。随访时，普通人群中约15%的中年男性存在严重酒精问题。在普通内科对酗酒者进行评估和治疗将对酒精相关疾病的总体问题产生非常重大的影响。
