Orgul Gokcen, Ozyuncu Ozgur, Oktem Ahmet, Beksac M Sinan
Division of Perinatology, Department of Obstetrics and Gynecology, Hacettepe University School of Medicine, Ankara, Turkey.
Department of Neonatology, Hacettepe University School of Medicine, Ankara, Turkey.
J Ultrasound. 2017 May 4;20(2):127-131. doi: 10.1007/s40477-017-0251-8. eCollection 2017 Jun.
Cystic hygroma (CH) is a fetal sonographic finding with an incidence of 1%. Chromosomal abnormalities and structural malformations are commonly related with CH. We aimed to describe our experience and determine the association between diagnosis of CH and adverse pregnancy outcome.
We retrospectively reviewed data of prenatal CH diagnoses over a ten-year period. Cases were evaluated for maternal age, gestational week at CH diagnosis, invasive procedure, karyotype result, associated abnormality and perinatal outcome. We categorized cases into two groups to understand the impact of maternal age on perinatal outcomes, and the cut-off was 35 years old.
Totally 28 individuals were enrolled in the study. The median maternal age at birth was 27.5 years old, and 7 patients were over 35 years old. Karyotype results were available for all individuals, and 15 had an abnormal chromosome (53.5%). Five fetuses had structural abnormalities, and they were all observed within patients under 35 years old. Healthy fetuses (without any problem at antenatal screening and birth) were found to be only 14.3% in advanced maternal age (AMA) group and 33.3% in young mothers.
Women with AMA and CH had a higher risk of having a baby with a chromosomal abnormality, as compared with younger women.
颈部水囊瘤（CH）是一种胎儿超声检查发现，发病率为1%。染色体异常和结构畸形通常与CH相关。我们旨在描述我们的经验，并确定CH诊断与不良妊娠结局之间的关联。
我们回顾性分析了十年间产前CH诊断的数据。对病例进行了产妇年龄、CH诊断时的孕周、侵入性检查、核型结果、相关异常和围产期结局的评估。我们将病例分为两组，以了解产妇年龄对围产期结局的影响，分界点为35岁。
共有28例患者纳入研究。产妇出生时的中位年龄为27.5岁，7例患者年龄超过35岁。所有个体均有核型结果，15例染色体异常（53.5%）。5例胎儿有结构异常，均在35岁以下患者中观察到。高龄产妇（AMA）组健康胎儿（产前筛查和出生时无任何问题）仅占14.3%，年轻母亲组为33.3%。
与年轻女性相比，AMA合并CH的女性生育染色体异常婴儿的风险更高。
