Bourne-Branchu Yann, Gosmini Corinne, Danoun Grégory
LCM, CNRS, Ecole Polytechnique, Université Paris-Saclay, 91128, Palaiseau Cedex, France.
Chemistry. 2017 Jul 26;23(42):10043-10047. doi: 10.1002/chem.201702608. Epub 2017 Jul 5.
The first cobalt-catalyzed amide activation of N-Boc-amides, and their conversion into esters, is reported here. This new methodology presents a very practical process that does not require an inert atmosphere, uses an inexpensive cobalt catalyst, and proceeds under mild reaction conditions. This catalytic system has a broad substrate scope and has been shown to be highly efficient, with catalyst loadings as low as 1 mol %.
本文报道了首例钴催化的N-叔丁氧羰基酰胺的酰胺活化反应及其向酯的转化。这种新方法提供了一个非常实用的过程，该过程不需要惰性气氛，使用廉价的钴催化剂，并且在温和的反应条件下进行。该催化体系具有广泛的底物范围，并且已被证明具有高效性，催化剂负载量低至1 mol%。
