减少新生儿和儿童乙肝疫苗接种剂量

Hepatitis B immunisation with a reduced number of doses in newborn babies and children.

作者信息

Piazza M, Picciotto L, Villari R, Guadagnino V, Orlando R, Isabella L, Macchia V, Memoli A M, Vegnente A, Borrelli A M

出版信息

Lancet. 1985 Apr 27;1(8435):949-51. doi: 10.1016/s0140-6736(85)91726-x.

Abstract

74 healthy babies born to mothers positive for hepatitis B surface antigen (HBsAg) were randomly divided at birth to receive either HB immunoglobulin and 2 doses of HB vaccine 2 months apart, or HB immunoglobulin and 3 doses of HB vaccine 1 month apart. 80 healthy babies born to HBsAg, anti-HBs, and anti-HB core (c) negative mothers were randomly divided at birth to receive either 2 doses of vaccine 2 months apart or 3 doses 1 month apart. The seroconversion rates and the geometric means of anti-HBs titres were lower in both groups of babies given 2 doses of vaccine than in the groups given 3 doses. 60 pairs of children at risk, aged 1 to 12 years and HBsAg, anti-HBs, and anti-HBc negative, were randomly divided to receive either the 2-dose regimen or the 3-dose regimen. The seroconversion rates and the geometric means of anti-HBs titres were satisfactory in both groups.

摘要

74名母亲乙肝表面抗原（HBsAg）呈阳性的健康婴儿在出生时被随机分组，一组接受乙肝免疫球蛋白和两剂间隔两个月的乙肝疫苗，另一组接受乙肝免疫球蛋白和三剂间隔一个月的乙肝疫苗。80名母亲乙肝表面抗原、乙肝表面抗体和乙肝核心抗体均为阴性的健康婴儿在出生时被随机分组，一组接受两剂间隔两个月的疫苗，另一组接受三剂间隔一个月的疫苗。接受两剂疫苗的两组婴儿的血清转化率和抗-HBs滴度几何均值均低于接受三剂疫苗的组。60对年龄在1至12岁、乙肝表面抗原、乙肝表面抗体和乙肝核心抗体均为阴性的高危儿童被随机分组，分别接受两剂方案或三剂方案。两组的血清转化率和抗-HBs滴度几何均值均令人满意。