ZMPSTE24是干扰素诱导跨膜抗病毒活性的下游效应分子。
ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity.
作者信息
Li Shitao, Fu Bishi, Wang Lingyan, Dorf Martin E
机构信息
1 Department of Physiological Sciences, Oklahoma State University , Stillwater, Oklahoma.
2 Department of Microbiology and Immunobiology, Harvard Medical School , Boston, Massachusetts.
出版信息
DNA Cell Biol. 2017 Jul;36(7):513-517. doi: 10.1089/dna.2017.3791. Epub 2017 Jun 8.
Abstract
The zinc metalloprotease ZMPSTE24 is a constitutively and ubiquitously expressed host restriction factor that is responsible for limiting infection by a broad spectrum of enveloped viruses, including influenza A, vesicular stomatitis, zika, ebola, Sindbis, cowpox, and vaccinia viruses, but not murine leukemia or adenovirus. Antiviral function is independent of ZMPSTE24 enzymatic activity. Protein interaction and genetic complementation studies indicate that ZMPSTE24 is a component of a common antiviral pathway that is associated with interferon-induced transmembrane proteins. In vivo studies with zmpste24-deficient mice demonstrate the importance of ZMPSTE24 for antiviral defense.
摘要
锌金属蛋白酶ZMPSTE24是一种组成性且广泛表达的宿主限制因子，负责限制多种包膜病毒的感染，包括甲型流感病毒、水疱性口炎病毒、寨卡病毒、埃博拉病毒、辛德毕斯病毒、牛痘病毒和痘苗病毒，但不包括小鼠白血病病毒或腺病毒。抗病毒功能独立于ZMPSTE24的酶活性。蛋白质相互作用和基因互补研究表明，ZMPSTE24是与干扰素诱导的跨膜蛋白相关的常见抗病毒途径的一个组成部分。对zmpste24基因缺陷小鼠的体内研究证明了ZMPSTE24在抗病毒防御中的重要性。
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