Serra Monica C, Blumenthal Jacob B, Addison Odessa R, Miller Ann J, Goldberg Andrew P, Ryan Alice S
Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, MD, USA.
Ann Nutr Metab. 2017;70(4):312-320. doi: 10.1159/000475766. Epub 2017 Jun 9.
BACKGROUND/AIMS: The purpose was to determine whether lifestyle interventions have different effects on regional fat in women with normal glucose tolerance vs. impaired glucose tolerance (NGT vs. IGT).
Changes in glucose metabolism (2-h oral glucose-tolerance tests), android to gynoid fat mass ratio (dual energy X-ray absorptiometry [DXA]), visceral to subcutaneous abdominal fat area ratio (CT), and abdominal to gluteal subcutaneous fat cell weight (FCW; adipose tissue biopsies) were determined in 60 overweight postmenopausal women (45-80 years) following 6 months of weight loss alone (WL; n = 28) or with aerobic exercise (AEX + WL; n = 32).
The interventions led to ∼8% decrease in weight, but only the AEX + WL group improved fitness (↑11% in VO2max) and reduced the android-to-gynoid fat mass ratio (↓5%; p < 0.05). Both NGT and IGT groups reduced visceral and subcutaneous abdominal fat areas and abdominal and gluteal FCWs, which related to improvements in homeostatic model assessment (r = 0.34-0.42) and 2-h glucose (r = 0.34-0.35), respectively (p < 0.05). The decline in FCW was 2× greater in women with IGT following WL (p < 0.05). The ratios of abdominal-to-gluteal FCW did not change following either intervention.
The mechanisms by which WL with and without exercise impact regional fat loss should be explored as reductions in abdominal fat area and subcutaneous FCW appear to influence glucose metabolism. This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply. Published by S. Karger AG, Basel.
背景/目的：本研究旨在确定生活方式干预对糖耐量正常与糖耐量受损女性（NGT与IGT）的局部脂肪是否有不同影响。
对60名超重绝经后女性（45 - 80岁）进行研究，她们在单独进行6个月体重减轻（WL；n = 28）或同时进行有氧运动（AEX + WL；n = 32）后，测定葡萄糖代谢变化（2小时口服葡萄糖耐量试验）、男性型与女性型脂肪量比值（双能X线吸收法[DXA]）、内脏与皮下腹部脂肪面积比值（CT）以及腹部与臀皮下脂肪细胞重量（FCW；脂肪组织活检）。
干预使体重下降约8%，但只有AEX + WL组改善了体能（最大摄氧量↑11%）并降低了男性型与女性型脂肪量比值（↓5%；p < 0.05）。NGT组和IGT组均减少了内脏和皮下腹部脂肪面积以及腹部和臀FCW，这分别与稳态模型评估改善（r = 0.34 - 0.42）和2小时血糖改善（r = 0.34 - 0.35）相关（p < 0.05）。IGT女性在WL后FCW下降幅度是其2倍（p < 0.05）。两种干预后腹部与臀FCW比值均未改变。
由于腹部脂肪面积和皮下FCW的减少似乎会影响葡萄糖代谢，因此应探索有运动和无运动的体重减轻影响局部脂肪减少的机制。本研究属美国政府工作，在美国不受版权保护。可能适用外国版权。由巴塞尔的S. Karger AG出版。
